Jason R. Vogel

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Felbamate (2-phenyl-1,3-propanediol dicarbamate) is a novel agent effective against maximal electroshock, pentylenetetrazol and other chemically induced seizures in mice and rats. Felbamate has been proposed as a novel anticonvulsant for the treatment of generalized tonic-clonic and complex partial seizures. In addition, felbamate has been shown to have(More)
Taste aversions reflect the association of drug-produced noxious interoceptive stimuli with distinctive tastes. In the present experiments, taste aversions to sweetened condensed milk were induced in rats by a wide range of doses of the hypnotic drugs, hexobarbital, amobarbital, chloral hydrate, flurazepam and methaqualone and by anesthetization with ethyl(More)
Taste aversions are induced by a variety of psychotropic drugs. In the present experiments taste aversions induced by the barbiturate hypnotic drug, amobarbital, were dramatically reduced by prior exposure to the drug. Increasing numbers of pre-exposures were associated with larger reductions in taste aversions. Reductions in sleeping time (a widely(More)
Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Although this report is in the public domain, permission must be secured from the individual copyright owners to reproduce any copyrighted materials contained within this report. Front cover: (top left) Collecting water from(More)
Tritiated thymidine ([3H]Tdr) was injected either intraocularly (i.o.) or intraperitoneally (i.p.). Autoradiography showed that more retinal cells were labeled by i.o. than by i.p. injection. Controls showed that the increased number of labeled retinal cells was not related to glioblast proliferation produced by trauma from the i.o. injection. After(More)
Learned taste aversions, as measured by increased time to complete 100 licks of a sweetened condensed milk solution, were demonstrated by laboratory rats 4 days after consumption of the milk solution paired with high oral doses of monosodium 1-glutamate (MSG). The hesitancy of the rats to consume milk on the test session cannot be simply attributed to(More)
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