Jason R. Gilder

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Sir: Observer effects are rooted in the universal human tendency to interpret data in a manner consistent with one’s expectations (1). This tendency is particularly likely to distort the results of a scientific test when the underlying data are ambiguous and the scientist is exposed to domain-irrelevant information that engages emotions or desires (2).(More)
When the smaller of two peaks at an STR locus is less than 70% the magnitude of the larger peak at that locus, the disparity is typically taken to be an indication that there is more than one contributor of template DNA to the sample being tested. An analysis of 1,763 heterozygous allele pairs suggests that a peak height imbalance threshold that varies with(More)
Dear Sir, A challenge to the reliability of low copy number (LCN) DNA profiling in the trial of Sean Hoey in Belfast Crown Court in Northern Ireland (R v Hoey [2007] NICC 49, 20 December, 2007) prompted the UK’s new Forensic Science Regulator (Andrew Rennison) to commission a review of low template DNA profiling techniques. That review [2], conducted by(More)
STR-based DNA profiling is an exceptionally sensitive analytical technique that is often used to obtain results at the very limits of its sensitivity. The challenge of reliably distinguishing between signal and noise in such situations is one that has been rigorously addressed in numerous other analytical disciplines. However, an inability to determine(More)
DNA profiling using STRs on the 310 and 3100 Genetic Analyzers routinely generates electropherograms that are analyzed with the GeneScan software available from the instrument's manufacturer, Applied Biosystems. Users have been able to choose from three different smoothing options that have been known to result in significant differences in the peak heights(More)
Finding new and exciting senior design projects for undergraduate computer engineers can be challenging for both students and faculty advisors. The challenge is even more pronounced when attempting to construct interdisciplinary design projects to better meet ABET 2000 criteria and to better prepare graduating students for careers as engineers. We present(More)
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