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Improvements in motor sequence performance have been observed after a delay involving sleep. This finding has been taken as evidence for an active sleep consolidation process that enhances subsequent performance. In a review of this literature, however, the authors observed 4 aspects of data analyses and experimental design that could lead to improved(More)
CONTEXT Establishing the long-term benefit of therapy in chronic diseases has been challenging. Long-term studies require non-randomized designs and, thus, are often confounded by biases. For example, although disease-modifying therapy in MS has a convincing benefit on several short-term outcome-measures in randomized trials, its impact on long-term(More)
UNLABELLED BACKGROUND Patients with severe sepsis or septic shock often exhibit significant cardiovascular dysfunction. We sought to determine whether severity of diastolic dysfunction assessed by transthoracic echocardiography (TTE) predicts 28-day mortality. METHODS In this prospective, observational study conducted in two intensive care units at a(More)
OBJECTIVES The objectives of this study were to assess the reactions of adult patients and parents of children with metabolic conditions to receipt of an "information prescription" (IP) to visit Genetics Home Reference (GHR), a National Institutes of Health/National Library of Medicine online resource, and evaluate the perceived utility of information found(More)
BACKGROUND Sepsis is an often-fatal syndrome resulting from severe infection. Rapid identification and treatment are critical for septic patients. We therefore developed a probabilistic model to identify septic patients in the emergency department (ED). We aimed to produce a model that identifies 80 % of sepsis patients, with no more than 15 false positive(More)
BACKGROUND We evaluated our previously derived admission criteria for agreement with physician decisions and outpatient failure among patients presenting to emergency departments (EDs) with pneumonia. METHODS Among patients presenting to seven Intermountain EDs in the urban region of Utah with pneumonia December 1 2009-December 1 2010, we measured(More)
BACKGROUND Patients' perceptions of the quality of their hospitalization have become important to the American healthcare system. Standard surveys of perceived quality of healthcare do not focus on the Intensive Care Unit (ICU) portion of the stay. Our objective was to evaluate the construct validity and internal consistency of the Intermountain Patient(More)
BACKGROUND Our purpose was to develop and test a predictive model of the acute glucose response to exercise in individuals with type 2 diabetes. DESIGN AND METHODS Data from three previous exercise studies (56 subjects, 488 exercise sessions) were combined and used as a development dataset. A mixed-effects Least Absolute Shrinkage Selection Operator(More)
BACKGROUND Ketamine was first synthesized in 1962 by Dr. Calvin Stevens of Wayne State University while at Parke Davis Laboratories. 1 His work at the time was investigating an alternative anesthetic to phencyclidine (PCP), less likely to cause seizures or neurotoxicity. As such, Ketamine is a dissociative anesthetic, similar in chemical structure to PCP,(More)
BACKGROUND Regular walking is a recommended but underused self-management strategy for individuals with type 2 diabetes mellitus (T2DM). OBJECTIVE To test the impact of a simulation-based intervention on the beliefs, intentions, knowledge, and walking behavior of individuals with T2DM. We compared two versions of a brief narrated simulation. The(More)
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