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Little is known about the effects of aging on synapses in the mammalian nervous system. We examined the innervation of individual mouse submandibular ganglion (SMG) neurons for evidence of age-related changes in synapse efficacy and number. For approximately 85% of adult life expectancy (30 months) the efficacy of synaptic transmission, as determined by(More)
1 Reflected light profilometer … ABSTRACT We present an instrument that uses a novel technique to render topographical maps of microscopic reflecting surfaces in which depth resolution can be an order or magnitude or more better than the lateral resolution of the confocal microscope. In a confocal scanning reflected-light microscope, the illumination light(More)
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