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The objective of this study was to evaluate whether heart rate variability (HRV) can be used as an index of parasympathetic reactivation after exercise. Heart rate recovery after exercise has recently been shown to have prognostic significance and has been postulated to be related to abnormal recovery of parasympathetic tone. Ten normal subjects [5 men and(More)
Dominant frequency analysis of atrial electrograms has been used to understand the pathophysiology of atrial fibrillation (AF). Although dominant frequency is an effective tool to estimate activation rate during AF, other factors besides activation rate may alter the results. Therefore, an adequate conceptual understanding of frequency domain analysis is(More)
INTRODUCTION Dominant frequency (DF) analysis of atrial electrograms has been used to characterize atrial fibrillation (AF). The aim of this study was to explore technical issues that may affect the estimation of local activation rate during AF using DF analysis. METHODS AND RESULTS Epicardial atrial electrograms recorded during AF from 10 dogs were used(More)
BACKGROUND Dominant frequency analysis has become a widely used tool for studying the pathophysiology of atrial fibrillation (AF). OBJECTIVES The purpose of this study was to compare dominant frequency with atrial activation rates in the presence of changing activation intervals and amplitudes and the complex morphologies characteristic of AF(More)
INTRODUCTION Complex fractionated atrial electrograms (CFAE) have been identified as targets for atrial fibrillation (AF) ablation. Robust automatic algorithms to objectively classify these signals would be useful. The aim of this study was to evaluate Shannon's entropy (ShEn) and the Kolmogorov-Smirnov (K-S) test as a measure of signal complexity and to(More)
BACKGROUND Prior studies report less favorable sleep characteristics among non-Whites as compared with non-Hispanic Whites. However, few population-based studies have used objective measures of sleep duration, especially in more than two racial/ethnic groups. We tested whether objectively estimated sleep duration and self-reported sleep quality varied by(More)
OBJECTIVES The purpose of this study was to investigate the electrophysiologic profile of the pulmonary veins (PVs) and left atrium (LA) in response to autonomic manipulation. BACKGROUND The parasympathetic innervation of the PVs and posterior left atrium (PLA) is thought to contribute to focal atrial fibrillation (AF). We hypothesized that autonomic(More)
BACKGROUND Early repolarization, indicated on the standard 12-lead ECG, has recently been associated with idiopathic ventricular fibrillation in patients without structural heart disease. It is unknown whether there is an association between early repolarization and ventricular arrhythmias in the coronary artery disease (CAD) population. METHODS AND(More)
AIMS The parasympathetic nervous system is thought to play a key role in atrial fibrillation (AF). Since parasympathetic signalling is primarily mediated by the heterotrimeric G-protein, Galpha(i)betagamma, we hypothesized that targeted inhibition of Galpha(i) interactions in the posterior left atrium (PLA) would modify the substrate for vagal AF. METHODS(More)