Jason Miller

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We present and evaluate the design of Deep Maize, our entry in the 2005 Trading Agent Competition Supply Chain Management scenario. The central idea is to decompose the problem by estimating the value of key resources in the game. We first create a high-level production schedule that considers cross-cutting constraints and future decisions, but abstracts(More)
PURPOSE We describe the use of chick chorioallantoic membrane (CAM) as a model system for the study of the precision and safety of vitreoretinal microsurgical instruments and techniques. METHODS The CAM was prepared for experimentation with and without its inner shell membrane (ISM) attached for in vivo and in vitro experiments that simulated medical and(More)
Autophagy is an intracellular turnover pathway. It has special relevance for neurodegenerative proteinopathies, such as Alzheimer disease, Parkinson disease, and Huntington disease (HD), which are characterized by the accumulation of misfolded proteins. Although induction of autophagy enhances clearance of misfolded protein and has therefore been suggested(More)
Huntington disease is a genetic neurodegenerative disorder that arises from an expanded polyglutamine region in the N terminus of the HD gene product, huntingtin. Protein inclusions comprised of N-terminal fragments of mutant huntingtin are a characteristic feature of disease, though are likely to play a protective role rather than a causative one in(More)
Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies, this may be a neuronal coping response to more toxic forms of(More)
Abnormal polyglutamine (polyQ) tracts are the only common feature in nine proteins that each cause a dominant neurodegenerative disorder. In Huntington's disease, tracts longer than 36 glutamines in the protein huntingtin (htt) cause degeneration. In situ, monoclonal antibody 3B5H10 binds to different htt fragments in neurons in proportion to their(More)
Future market conditions can be a pivotal factor in making business decisions. We present and evaluate methods used by our agent, Deep Maize, to forecast market prices in the Trading Agent Competition Supply Chain Management Game. As a guiding principle we seek to exploit as many sources of available information as possible to inform predictions. Since(More)
BACKGROUND Application of pulsed radiofrequency (PRF) currents to the dorsal root ganglia (DRG) has been reported to produce relief from certain pain states without causing thermal ablation. In this study, we examined the direct correlation between PRF application to DRG associated with spinal nerve injury and reversal of injury-induced behavioral(More)
ABSTRACT We illustrate developing techniques for empirical game-theoretic analysis by application to two challenging market games employed in an annual Trading Agent Competition. These games exemplify relevant environments beyond analytic tractability, yet which can be investigated experimentally through simulation and careful measurement. Our analysis of(More)
The TAC SCM tournament is moving into its fourth year. In an effort to track agent progress, we present a benchmark market efficiency comparison for the tournament, in addition to prior measures of agent competency through customer bidding. Using these benchmarks we find statistically significant increases in intratournament market efficiency, whereas(More)