Jason M. Low

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OBJECTIVE Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been found in sera of 76% of patients with rheumatoid arthritis (RA), mainly in rheumatoid factor (RF) positive patients, with a specificity of 96%. We evaluated the presence of anti-CCP antibodies in patients with juvenile idiopathic arthritis (JIA) and assessed the possibility of(More)
OBJECTIVE To evaluate in juvenile idiopathic arthritis (JIA) patients a biomarker panel of anti-cyclic citrullinated peptide (anti-CCP) antibodies, cartilage oligomeric matrix protein (COMP), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), IgM rheumatoid factor (RF), IgG RF, and IgA RF and compare to the presence of joint erosions (JE),(More)
The hemodynamic effects of methohexital, at infusion rates of 60-65 and 120 micrograms/kg/min with concomitant inhalation of 67% nitrous oxide in oxygen, have been studied during spontaneous and controlled ventilation in 8 patients. Under most of the conditions studied methohexital infusion anesthesia was associated with lower arterial pressure (-13% to(More)
Plasma adrenaline and noradrenaline concentrations were measured in 10 consecutive patients during functional endoscopic sinus surgery (FESS). Surgery was preceded by nasal packing with 5 ml 2% cocaine solution, followed by infiltration with 1:80,000 adrenaline and 2% lignocaine. All patients showed a marked rise in plasma adrenaline concentration within 4(More)
OBJECTIVE Video-assisted thoracoscopic surgery (VATS) is now widely practised in adults but there are few publications on its application in the paediatric population. METHODOLOGY Retrospective review of the authors' experience with VATS in children under 16 years old during an 18 month period in a university teaching hospital. RESULTS From September(More)
Video-assisted thoracoscopy (VAT) offers a new approach to the diagnosis and treatment of many thoracic conditions. From September 1992 to August 1993, a total of 163 VAT procedures were successfully performed on 108 patients (87 male, 21 female; age range from 12 to 77) which consisted of 42 bleb eliminations and 64 mechanical pleurodesis for spontaneous(More)
Previous studies on oxygen consumption ( $$\dot V_{O_2 } $$ ) during weaning from mechanical ventilation assumed that an increase in $$\dot V_{O_2 } $$ (Δ $$\dot V_{O_2 } $$ ) reflected oxygen consumption by respiratory muscles ( $$\dot V_{O_2 RESP} $$ ), and proposed Δ $$\dot V_{O_2 } $$ as a weaning predictor. We measured $$\dot V_{O_2 } $$ CO2 production(More)
Patients with juvenile idiopathic arthritis (JIA) have been shown to have elevated levels of circulating immune complexes (CICs) which correlated with disease activity. Our aim was to assess B cell activity by measuring the amount of and the kappa:lambda chain immunoglobulin light (L) chain ratio in CICs from JIA patients and to determine potential evidence(More)
Arterial pressure and plasma catecholamine concentrations were measured in 16 normotensive and 10 hypertensive patients undergoing elective vascular surgery. Following induction of anaesthesia, both arterial pressure and plasma noradrenaline concentrations decreased in both groups. Following laryngoscopy, there was a moderate increase in arterial pressure(More)
The production of autoreactive antibodies from self-reactive B cells results in the formation of immune complexes that deposit in tissue and fix complement, contributing to the pathogenesis of rheumatoid arthritis (RA). Earlier mouse models emphasize the importance of autoreactive antibodies formed against "self" proteins that serve as a source for T(More)