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The interleukin 1 receptor (IL-1R) and the Toll-like receptors (TLRs) are highly homologous innate immune receptors that provide the first line of defense against infection. We show that IL-1R type I (IL-1RI) is essential for TLR9-dependent activation of tumor necrosis factor receptor-associated factor 3 (TRAF3) and for production of the antiinflammatory(More)
This paper investigates the cache sizes and configurations that can be supported by a high frequency processor of the next generation. Based on the SIA roadmap prediction that a 0.1u processor of the next generation will run at 3.5GHz, we model caches of that technology using the CACTI tool. Access times as well as energy consumption are modeled for caches(More)
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of development. Therapies that overcome differentiation arrest represent a powerful treatment strategy. We leveraged the observation that the majority of AML, despite their genetically(More)
Soon if not already, multimedia applications such as those that deal with the creation, processing, and communication of digital images, digital audio, and digital video are expected to become one of the dominant computing workloads [6]. Most modern general-purpose processors employ a set of instruction extensions to their architecture to enhance the(More)
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