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BACKGROUND The relative ease of targeted gene disruption in the social amoeba Dictyostelium has stimulated its widespread use as an experimental organism for cell and developmental biology. However, the field has been hamstrung by the lack of techniques to recombine disrupted genes. RESULTS We describe new techniques for parasexual fusion of strains in(More)
Software engineers often implement logging mechanisms to debug software and diagnose faults. As modern software manages increasingly sensitive data, logging mechanisms also need to capture detailed traces of user activity to enable forensics and hold users accountable. Existing techniques for identifying what events to log are often subjective and produce(More)
  • Jason King, Melanie Keim, Regina Teo, Karin E. Weening, Mridu Kapur, Karina McQuillan +5 others
  • 2010
Lithium (Li(+)) is a common treatment for bipolar mood disorder, a major psychiatric illness with a lifetime prevalence of more than 1%. Risk of bipolar disorder is heavily influenced by genetic predisposition, but is a complex genetic trait and, to date, genetic studies have provided little insight into its molecular origins. An alternative approach is to(More)
BACKGROUND Cell motility is an essential feature of the pathogenesis and morbidity of amoebiasis caused by Entamoeba histolytica. As motility depends on cytoskeletal organisation and regulation, a study of the molecular components involved is key to a better understanding of amoebic pathogenesis. However, little is known about the physiological roles,(More)
Sporadic inclusion body myositis (sIBM) is the most common myopathy in people over the age of 50 years. While immune-mediated inflammatory myopathies are well documented in dogs, sIBM has not been described. An 11-year-old dog with chronic and progressive neuromuscular dysfunction was evaluated for evidence of sIBM using current pathologic,(More)
User activity logs should capture evidence to help answer who, what, when, where, why, and how a security or privacy breach occurred. However, software engineers often implement logging mechanisms that inadequately record mandatory log events (MLEs), user activities that must be logged to enable forensics. The objective of this study is to support security(More)
Ideally, software engineering courses should adequately reflect real-world software development so that students obtain a better understanding and experience with practices and techniques used in industry. <i>Our objective is to improve software engineering courses by incorporating best practices for automated software engineering and facilitating rapid(More)
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