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Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.
Clinical studies have suggested that myocardial iron is a risk factor for left ventricular remodeling in patients after myocardial infarction. Ferroptosis has recently been reported as a mechanism ofExpand
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The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus
Purpose of ReviewT2DM (type 2 diabetes mellitus) is a risk factor for heart failure. The mTOR (mechanistic target of rapamycin) is a key mediator of the insulin signaling pathway. We will discuss theExpand
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Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion.
Diet-induced obesity deteriorates the recovery of cardiac function after ischemia-reperfusion (I/R) injury. While mechanistic target of rapamycin (mTOR) is a key mediator of energy metabolism, theExpand
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Impact of Sustained Exposure to β-Amyloid on Calcium Homeostasis and Neuronal Integrity in Model Nerve Cell System Expressing α4β2 Nicotinic Acetylcholine Receptors*
Background: The consequence of sustained exposure of nicotinic receptors to β-amyloid is unknown. Results: Sustained exposure to β-amyloid potentiated nicotinic receptor function, promoting oxidativeExpand
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Pathological Roles of Iron in Cardiovascular Disease.
Iron is an essential mineral required for a variety of vital biological functions. Despite being vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factorExpand
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Phyllostachys edulis Compounds Inhibit Palmitic Acid-Induced Monocyte Chemoattractant Protein 1 (MCP-1) Production
Background Phyllostachys edulis Carriere (Poaceae) is a bamboo species that is part of the traditional Chinese medicine pharmacopoeia. Compounds and extracts from this species have shown potentialExpand
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Guidelines for evaluating myocardial cell death.
Cell death is a fundamental process in cardiac pathologies. Recent studies revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling andExpand
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Bamboo extract reduces interleukin 6 (IL-6) overproduction under lipotoxic conditions through inhibiting the activation of NF-κB and AP-1 pathways.
Interleukin 6 (IL-6) is an inflammatory cytokine overexpressed in obese individuals that contributes to the development of diseases such as insulin resistance, type 2 diabetes, and cardiovascularExpand
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Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat.
Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine up-regulated in obese subjects, contributing to the development of type 2 diabetes. The present study investigated theExpand
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Three‐dimensional myocardial scarring along myofibers after coronary ischemia–reperfusion revealed by computerized images of histological assays
Adverse left ventricular (LV) remodeling after acute myocardial infarction is characterized by LV dilatation and development of a fibrotic scar, and is a critical factor for the prognosis ofExpand
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