Learn More
PURPOSE The purpose of our study was to test the prediction that if the tear film thins due to evaporation, rather than tangential flow, a high concentration of fluorescein in the tear film would show a greater reduction in fluorescent intensity compared to a low concentration of fluorescein due to self-quenching at high concentrations. METHODS Tear film(More)
PURPOSE To apply interferometry as an in vivo measure of tear film thinning between blinks. METHODS Wavelength-dependent interference was used to measure the tear film thinning rates in 20 normal contact lens wearers, and spectra were captured at a rate of 4.5 per second for 20 seconds. Four recordings of precorneal tear film (PCTF) thinning were made,(More)
PURPOSE Tear evaporation should increase fluorescein concentration, causing fluorescence dimming from self-quenching for high but not low fluorescein concentration. This prediction was tested and compared to the predicted effect of "tangential flow" that fluorescence dimming should be similar for high and low concentrations. METHODS A custom optical(More)
PURPOSE The thinning of the precorneal tear film between blinks and tear film breakup can be logically analyzed into contributions from three components: evaporation, flow into the cornea, and tangential flow along the corneal surface. Whereas divergent tangential flow contributes to certain types of breakup, it has been argued that evaporation is the main(More)
BACKGROUND The purpose of this report was to examine the relation between clinical tests and dry eye symptoms in patients with dry eye disease. METHODS Seventy-five patients with dry eye disease (ICD-9 code 375.15) were included in these analyses. There was no specific entry criterion for enrollment in addition to a previous dry eye diagnosis in this(More)
PURPOSE The purpose of this study was to compare the agreement within and between examiners when evaluating real-time and digital photographs of TearScope Plus tear film interference patterns. We also evaluated between-examiner agreement of noninvasive digital tear break-up time (NITBUT) using the TearScope, the relation between NITBUT and tear film(More)
PURPOSE Orthokeratology is defined as the temporary reduction in myopia by the programmed application of rigid gas-permeable contact lenses. New reverse geometry contact lens designs and materials have led to a renewed interest in this field. The purpose of this study is to assess visual, refractive, topographic, and corneal thickness changes in subjects(More)
PURPOSE To evaluate an interferometric method for measuring the thickness of the pre- (PLTF) and postlens tear film (POLTF) in subjects wearing hydrogel contact lenses. The precision and accuracy of measuring postlens tear thickness is compared with a previous method based on optical pachymetry and mechanical measurement of contact lens thickness. METHODS(More)
PURPOSE The aims of this analysis were to determine if there is an association between serum levels of testosterone and estradiol with meibomian gland (MG) morphology and lipid layer thickness. METHODS The data used for this analysis were collected from postmenopausal women with and without dry eye disease. Meibography was used to assess MG dropout on the(More)