Jason J. Nichols

Learn More
BACKGROUND The purpose of this report was to examine the relation between clinical tests and dry eye symptoms in patients with dry eye disease. METHODS Seventy-five patients with dry eye disease (ICD-9 code 375.15) were included in these analyses. There was no specific entry criterion for enrollment in addition to a previous dry eye diagnosis in this(More)
PURPOSE To apply interferometry as an in vivo measure of tear film thinning between blinks. METHODS Wavelength-dependent interference was used to measure the tear film thinning rates in 20 normal contact lens wearers, and spectra were captured at a rate of 4.5 per second for 20 seconds. Four recordings of precorneal tear film (PCTF) thinning were made,(More)
PURPOSE To investigate whether the tear film thinning between blinks is caused by evaporation or by tangential flow of the tear film along the surface of the cornea. Tangential flow was studied by measuring the movement of the lipid layer. METHODS Four video recordings of the lipid layer of the tear film were made from 16 normal subjects, with the(More)
Scientists have been interested in studying the secretions of the meibomian glands for many years, and diseases associated with the meibomian glands (e.g., cancers, posterior blepharitis) have been noted in the medical literature since at least the early part of the 20th Century. However, the term “meibomian gland dysfunction” (MGD) was only introduced by(More)
PURPOSE The purpose of this work was to examine the tear film proteome using a combination of one-dimensional (1D) and two dimensional (2D) gel electrophoresis and mass spectrometry-based techniques and to explore the effect of the tear collection methods on the tear proteome. METHODS Tear samples from eight normal non-contact lens wearing human subjects(More)
PURPOSE To determine the contribution of evaporation to the thinning of the precorneal tear film between blinks. METHODS The rate of tear film thinning after a blink was measured using spectral interferometry from the right eyes of 37 subjects. Data were obtained under two different conditions: free air and air-tight goggles. RESULTS The mean (±SD) tear(More)
PURPOSE The purpose of our study was to test the prediction that if the tear film thins due to evaporation, rather than tangential flow, a high concentration of fluorescein in the tear film would show a greater reduction in fluorescent intensity compared to a low concentration of fluorescein due to self-quenching at high concentrations. METHODS Tear film(More)
PURPOSE Orthokeratology is defined as the temporary reduction in myopia by the programmed application of rigid gas-permeable contact lenses. New reverse geometry contact lens designs and materials have led to a renewed interest in this field. The purpose of this study is to assess visual, refractive, topographic, and corneal thickness changes in subjects(More)
PURPOSE To evaluate an interferometric method for measuring the thickness of the pre- (PLTF) and postlens tear film (POLTF) in subjects wearing hydrogel contact lenses. The precision and accuracy of measuring postlens tear thickness is compared with a previous method based on optical pachymetry and mechanical measurement of contact lens thickness. METHODS(More)
PURPOSE The complex superficial lipid layer of the tear film functions to prevent evaporation and maintain tear stability. Although classes of lipids found in the tear film have been reported, individual lipid species are currently being studied with more sophisticated. METHODS The purpose of this work was to show the identification of fatty acids and the(More)