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Capsular polysaccharides are important factors in bacterial pathogenesis and have been the target of a number of successful vaccines. Francisella tularensis has been considered to express a capsular antigen but none has been isolated or characterized. We have developed a monoclonal antibody, 11B7, which recognizes the capsular polysaccharide of F.(More)
Neisseria gonorrhoeae has been shown to form biofilms during cervical infection. Thus, biofilm formation may play an important role in the infection of women. The ability of N. gonorrhoeae to form membrane blebs is crucial to biofilm formation. Blebs contain DNA and outer membrane structures, which have been shown to be major constituents of the biofilm(More)
Bacterial flagella mediate host-microbe interactions through tissue tropism during colonization, as well as by activating immune responses. The flagellar shaft of some bacteria, including several human pathogens, is encased in a membranous sheath of unknown function. While it has been hypothesized that the sheath may allow these bacteria to evade host(More)
We have determined uterine glycogen content, metabolizing enzyme expression and activity in the mink, a species that exhibits obligatory embryonic diapause, resulting in delayed implantation. Gross uterine glycogen concentrations were highest in estrus, decreased 50% by diapause and 90% in pregnancy (P ≤ 0.05). Endometrial glycogen deposits, which localized(More)
Virtualization of network elements and the transition from embedded systems requires an extension of the existing paradigm of software lifecycle development and management to what traditionally has been done for each embedded system. In this paper IBM will cover the end-to-end design of such systems such that they can deliver deterministic, repeatable(More)
What is the problem and why is it hard? Global behavior in complex information systems, such as the Internet, computing grids, and service-oriented architectures, is difficult to measure, understand and control. Subtle interactions and indirect couplings through shared resources lead to emergent behaviors, which are not predictable from analyzing the(More)
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