Jason Harris

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The success of a genetic family study depends on the recruitment of a sufficient number of unaffected family members. We present our experiences from interviews performed in two family studies, a genetic family study of prostate cancer (PC) and a medical, anthropological, qualitative study. In the genetic family study, 949 PC patients were contacted, and(More)
Clinical genomic testing is dependent on the robust identification and reporting of variant-level information in relation to disease. With the shift to high-throughput sequencing, a major challenge for clinical diagnostics is the cross-identification of variants called on their genomic position to resources that rely on transcript- or protein-based(More)
Whole exome sequencing is increasingly used for the clinical evaluation of genetic disease, yet the variation of coverage and sensitivity over medically relevant parts of the genome remains poorly understood. Several sequencing-based assays continue to provide coverage that is inadequate for clinical assessment. Using sequence data obtained from the NA12878(More)
We present the spatially-resolved star formation and chemical enrichment history of the Small Magellanic Cloud (SMC) across the entire central 4 × 4.5 area of the main body, based on UBV I photometry from our Magellanic Clouds Photometric Survey. We find that 1) approximately 50% of the stars that ever formed in the SMC formed prior to 8.4 Gyr ago (z > 1.2(More)
We present an auditory biofeedback technique that may be used as a tool for stress management. The technique encourages slow breathing by adjusting the quality of a music recording in proportion to the user's respiration rate. We propose two forms of acoustic degradation, one that adds white noise to the recording if the user's breathing deviates from the(More)
The ACS Nearby Galaxy Survey Treasury (ANGST) is a large Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) treasury program to obtain resolved stellar photometry for a volume-limited sample of galaxies out to 4 Mpc. As part of this program, we have obtained deep ACS imaging of a field in the outer disk of the large spiral galaxy M81. The field(More)
Somatic mosaicism, the occurrence and propagation of genetic variation in cell lineages after fertilization, is increasingly recognized to play a causal role in a variety of human diseases. We investigated the case of life-threatening arrhythmia in a 10-day-old infant with long QT syndrome (LQTS). Rapid genome sequencing suggested a variant in the sodium(More)
We use the star formation history map of the Large Magellanic Cloud recently published by Harris & Zaritsky to study the sites of the eight smallest (and presumably youngest) supernova remnants in the Cloud: SN 1987A, N158A, N49, and N63A (core collapse remnants), 0509−67.5, 0519−69.0, N103B, and DEM L71 (Type Ia remnants). The local star formation(More)
We present multicolor photometry of bright star cluster candidates in the nearby starburst galaxies NGC 3077 and NGC 5253, observed with the Hubble Space Telescope Wide Field and Planetary Camera 2 in both broadband (F300W, F547M and F814W) and narrowband (F487N and F656N) filters. By comparing the photometry with theoretical population synthesis models, we(More)
The goal of this paper is to present the results of a preliminary analysis of the extended infrared (IR) emission by dust in the interstellar medium (ISM) of the Large Magellanic Cloud (LMC). We combine Spitzer Surveying the Agents of Galaxy Evolution (SAGE) and Infrared Astronomical Satellite (IRAS) data and correlate the infrared emission with gas tracers(More)