Jason Elliott

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Can 3D graphics help high-school students learn advanced mathematics? Can we create a sufficiently compelling application such that students would choose to play with advanced math concepts for fun? What usability problems does this technology pose for novice users? AquaMOOSE 3D is a desktop 3D environment designed to help students learn about the behavior(More)
Anti-VEGF therapy has been a clinically validated treatment of age-related macular degeneration (AMD). We have recently reported the discovery of indole based oral VEGFR-2 inhibitors that provide sustained ocular retention and efficacy in models of wet-AMD. We disclose herein the synthesis and the biological evaluation of a series of novel core replacements(More)
MOOSE Crossing is a text-based virtual reality environment (or “MUD”) designed to be a constructionist learning environment for children ages 8 to 12. We performed a portfolio-style assessment of children’s programming accomplishments in this environment. Analysis of the data reveals uneven levels of achievement—some children accomplish a great deal but the(More)
The advent of readily accessible, inexpensive Web-conferencing applications has opened the door for distance psychotherapy supervision, using video recordings of treated clients. Although relatively new, this method of supervision is advantageous given the ease of use and low cost of various Internet applications. This method allows periodic supervision(More)
The benefit of intravitreal anti-VEGF therapy in treating wet age-related macular degeneration (AMD) is well established. Identification of VEGFR-2 inhibitors with optimal ADME properties for an ocular indication provides opportunities for dosing routes beyond intravitreal injection. We employed a high-throughput in vivo screening strategy with rodent(More)