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A Monte Carlo method is given to compute the binding affinity of a ligand to a protein. The method involves extending configuration space by a discrete variable indicating whether the ligand is bound to the protein and a special Monte Carlo move, which allows transitions between the unbound and bound states. Provided that an accurate protein structure is(More)
Experimental and model studies were performed to measure the electrocardiographic surface Laplacian using a rectangular finite difference approximation. The experimental approach used ten normal subjects with two sites on the torso. Electrode spacing was 2 cm. The surface Laplacian is theoretically independent of rotation of the electrode array. The data(More)
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