Jason E. Blatt

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Recombinant factor VIIa (rFVIIa, NovoSeven) is FDA-approved for the treatment of bleeding in patients with hemophilia A/B with inhibitors. A growing literature suggests that there may be expanded indications for the use of NovoSeven in patients with significant bleeding who do not have a known factor deficiency. Severe bleeding refractory to standard(More)
A case report of a dramatic therapeutic response of Hodgkin's disease (HD) to diethylstilbestrol (DES) in a man who was being treated for concurrent prostate cancer suggested that there also may be a role for sex steroids in the pathogenesis of HD (1). High levels of estrogen receptors (ER) comparable to those seen in breast carcinoma cells were detected in(More)
This paper presents a segmentation technique to identify the medial axis and the boundary of cranial nerves. We utilize a 3-D deformable one-simplex discrete contour model to extract the medial axis of each cranial nerve. This contour model represents a collection of two-connected vertices linked by edges, where vertex position is determined by a Newtonian(More)
9563 Background: Temsirolimus (Tem), an inhibitor of the mammaliantarget of rapamycin (mTOR), and valproic acid (VPA), an inhibitor of histone deacetylase (HDAC), are both inducers of autophagy. Each has shown in vitro and in vivo antitumor activity against a range of cancers. Prior pediatric studies have established a maximumtolerated dose (MTD) for Tem of(More)
Wound healing and infection is a concern for all surgeons, especially in cases of repeat surgical intervention. The osteoplastic flap is a technique that was previously used frequently in cranial surgery but since the introduction of cranial plating systems, it is now used only rarely. A retrospective study showed that although the infection rates of(More)
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