Jason Doherty

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Alterations in the tissue microenvironment collaborate with cell autonomous genetic changes to contribute to neoplastic progression. The importance of the microenvironment in neoplastic progression is underscored by studies showing that fibroblasts isolated from a tumor stimulate the growth of preneoplastic and neoplastic cells in xenograft models.(More)
In-silico screening of flexible ligands against flexible ligand binding pockets (LBP) is an emerging approach in structure-based drug discovery. Here, we describe a molecular dynamics (MD) based docking approach to investigate the influence on the high-throughput in-silico screening of small molecules against flexible ligand binding pockets. In our(More)
BACKGROUND Performance on psychometric tests is key to diagnosis and monitoring treatment of dementia. Results are often reported as a total score, but there is additional information in individual items of tests which vary in their difficulty and discriminatory value. Item difficulty refers to an ability level at which the probability of responding(More)
Speech reminders can severely disrupt list recall. Spearcons, time-compressed speech messages, might be less disruptive because they are much shorter. In this study, we asked 24 younger participants to recall 64 short lists of digit, animal, food, or furniture names. List items were presented one at a time; the number of items presented depended on(More)
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