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Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senescence, establishing an essential role for(More)
Spot type net blotch caused by Pyrenophora teres f. maculata (Ptm) has become a prominent disease in Western Australia, as has also occurred elsewhere. The disease has a negative impact on both grain yield and quality resulting from reduced grain size. Lack of resistance and stubble retention are the likely factors in the increased severity of the disease(More)
The HCl in the mammalian stomach is concentrated enough to digest the stomach itself, yet the gastric epithelium remains undamaged. One protective factor is gastric mucus, which forms a protective layer over the surface epithelium and acts as a diffusion barrier Bicarbonate ions secreted by the gastric epithelium are trapped in the mucus gel, establishing a(More)
Basic fibroblast growth factor (FGF) is synthesized as a phosphoprotein by both bovine capillary endothelial and human hepatoma cells in culture. Because basic FGF is characterized by its high affinity for heparin and its association in vivo with the extracellular matrix, we examined the possibility that the phosphorylation of this growth factor by purified(More)
Cathepsin B (EC 3.4.22.1) was purified 746-fold with a 21% recovery from bovine brain by autolysis, fractional precipitation with acetone, carboxy-methyl-Sephadex chromatography, affinity chromatography on a cystamine containing column and gel filtration chromatography. The purified cathepsin B eluted on gel filtration with an apparent molecular weight of(More)
Barley powdery mildew caused by Blumeria graminis f. sp. hordei is a most devastating disease in Western Australia and elsewhere. The disease has a negative impact on grain yield and quality and, thus, affects its marketability. The detection of pathogen variability has further impacted sustainable barley production. Various isolates have been reported to(More)
We enumerate the genetic resources for coastal Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco vat. menziesit) in tree improvement programs in the Paci tic Northwest USA and evaluate how they contribute to gene conservation of the species. The first-generation programs include over four million progeny from 33,928 selections planted on 999 test sites.(More)
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