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Based on the recent literature and collective experience, an international consortium developed revised guidelines for the diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records and compared the sensitivity of proposed and earlier criteria in a multi-site sample of patients with(More)
Perception of the acoustic world requires the simultaneous processing of the acoustic patterns associated with sound objects and their location in space. In this functional magnetic resonance experiment, we investigated the human brain areas engaged in the analysis of pitch sequences and sequences of acoustic spatial locations in a paradigm in which both(More)
It is increasingly recognized that the human planum temporale is not a dedicated language processor, but is in fact engaged in the analysis of many types of complex sound. We propose a model of the human planum temporale as a computational engine for the segregation and matching of spectrotemporal patterns. The model is based on segregating the components(More)
BACKGROUND Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved. METHODS We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech(More)
There is great interest in using automatic computational neuroanatomy tools to study ageing and neurodegenerative disease. Voxel-based morphometry (VBM) is one of the most widely used of such techniques. VBM performs voxel-wise statistical analysis of smoothed spatially normalised segmented Magnetic Resonance Images. There are several reasons why the(More)
BACKGROUND Frontotemporal lobar degeneration (FTLD) is a clinically, genetically, and pathologically heterogeneous neurodegenerative disorder. Two subtypes commonly present with a language disorder: semantic dementia (SemD) and progressive nonfluent aphasia (PNFA). METHODS Patients meeting consensus criteria for PNFA and SemD who had volumetric MRI of(More)
The primary progressive aphasias (PPA) are paradigmatic disorders of language network breakdown associated with focal degeneration of the left cerebral hemisphere. Here we addressed brain correlates of PPA in a detailed neuroanatomical analysis of the third canonical syndrome of PPA, logopenic/phonological aphasia (LPA), in relation to the more widely(More)
Accumulating evidence in humans and non-human primates implicates the posterior superior temporal plane (STP) in the processing of both auditory spatial information and vocal sounds. Such evidence is difficult to reconcile with existing accounts of the primate auditory brain. We propose that the posteromedial STP generates sequenced auditory representations(More)
Objects are the building blocks of experience, but what do we mean by an object? Increasingly, neuroscientists refer to 'auditory objects', yet it is not clear what properties these should possess, how they might be represented in the brain, or how they might relate to the more familiar objects of vision. The concept of an auditory object challenges our(More)
We assessed the human brain network for sound-motion processing using the same virtual stimulus in three independent functional imaging experiments. All experiments show a bilateral posterior network of activation, including planum temporale (PT) and parieto-temporal operculum (PTO). This was demonstrated in contrasts between sound movement and two control(More)