Jason D. Doles

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Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regenerative capacity, which can lead to sarcopenia and increased mortality. Although the mechanisms underlying sarcopenia remain unclear, the skeletal muscle stem cell, or satellite cell, is required for muscle regeneration. Therefore, identification of(More)
Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and decreased regenerative capacity, which can lead to sarcopenia and increased mortality. While the mechanisms underlying sarcopenia remain unclear, the skeletal muscle stem cell, or satellite cell, is required for muscle regeneration. Therefore,(More)
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population. To understand the mechanisms involved in maintaining satellite cell quiescence, we identified gene transcripts that were differentially expressed during(More)
Transplanting adult stem cells provides a stringent test for self-renewal and the assessment of comparative engraftment in competitive transplant assays. Transplantation of satellite cells into mammalian skeletal muscle provided the first critical evidence that satellite cells function as adult muscle stem cells. Transplantation of a single satellite cell(More)
Release of muscle stem cells from quiescence involves the coordinated effort of transcription, mRNA stability, and translation. We focus this review on post-transcriptional regulation of muscle stem cells and highlight the impact of deregulated mRNA homeostasis on muscle aging and muscle disease pathogenesis.
31 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit 32 quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell 33 population. To understand the mechanisms involved in maintaining satellite cell quiescence, we 34 identified gene transcripts that were differentially expressed(More)
1094 volume 20 | number 10 | october 2014 nature medicine converts satellite cells to proliferating myoblasts, via a conserved STAT3 enhancer element. Additionally, Stat3 inhibitor studies in aged and dystrophic mice mirrored observations made by Price et al.2 demonstrating that inhibition of JAK-STAT signaling improves skeletal muscle regeneration. In both(More)
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