Jason D. Doles

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Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and decreased regenerative capacity, which can lead to sarcopenia and increased mortality. While the mechanisms underlying sarcopenia remain unclear, the skeletal muscle stem cell, or satellite cell, is required for muscle regeneration. Therefore,(More)
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population. To understand the mechanisms involved in maintaining satellite cell quiescence, we identified gene transcripts that were differentially expressed during(More)
31 Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit 32 quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell 33 population. To understand the mechanisms involved in maintaining satellite cell quiescence, we 34 identified gene transcripts that were differentially expressed(More)
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