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RNA polymerase II (RNAP II) is responsible for transcribing all messenger RNAs in eukaryotic cells during a highly regulated process that is conserved from yeast to human, and that serves as a… (More)
Most proteins that are to be imported into the mitochondrial matrix are synthesized as precursors, each composed of an N-terminal targeting sequence followed by a mature domain. Precursors are… (More)
Force microscopy techniques including optical trapping, magnetic tweezers, and atomic force microscopy (AFM) have facilitated quantification of forces and distances on the molecular scale. However,… (More)
When developing a new domain-specific architectural style, there can be uncertainty about the feasibility of using that style. In particular, the HADES architectural style contains refactoring… (More)
3 Ninning Liu, Gheorghe Chistol , Yuanbo Cui , Carlos Bustamante 1,2,3,4,5,6,7,* 4 Jason L. Choy Laboratory of Single Molecule Biophysics 5 Department of Molecular and Cell Biology, University of… (More)
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro… (More)