• Publications
  • Influence
Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency
Significance Herpesviruses have an extraordinarily complex relationship with their host, persisting for the lifetime of the host by way of a latent infection. Reactivation of replication isExpand
  • 69
  • 5
Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells
ABSTRACT The establishment of human cytomegalovirus (HCMV) latency and persistence relies on the successful infection of hematopoietic cells, which serve as sites of viral persistence and contributeExpand
  • 46
  • 3
Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation
Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long persistence in the host, like all herpesviruses, by way of a latent infection. During latency, viral genomes areExpand
  • 50
  • 3
  • PDF
Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency
Reactivation from latency requires reinitiation of viral gene expression and culminates in the production of infectious progeny. The major immediate early promoter (MIEP) of human cytomegalovirusExpand
  • 16
  • 3
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication
Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), aExpand
  • 51
  • 2
  • PDF
Influenza A Virus PB1-F2 Protein Expression Is Regulated in a Strain-Specific Manner by Sequences Located Downstream of the PB1-F2 Initiation Codon
ABSTRACT Translation of influenza A virus PB1-F2 occurs in a second open reading frame (ORF) of the PB1 gene segment. PB1-F2 has been implicated in regulation of polymerase activity, immunopathology,Expand
  • 13
  • 1
HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation
Reactivation of latent Human Cytomegalovirus (HCMV) in CD34+ hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cellExpand
  • 9
  • PDF
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency
Human cytomegalovirus (HCMV) establishes a lifelong latent infection in the human host. While the infection is typically asymptomatic in healthy individuals, HCMV infection poses life-threateningExpand
  • 15
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency
Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human cytomegalovirusExpand
  • 11
  • PDF
Alternative promoters drive human cytomegalovirus reactivation from latency
Significance Cytomegalovirus is a herpesvirus that persists latently for the host’s lifetime, with periodic reactivation that can cause life threatening disease in individuals with inadequateExpand
  • 8