Jason A. Vander Heiden

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UNLABELLED Advances in high-throughput sequencing technologies now allow for large-scale characterization of B cell immunoglobulin (Ig) repertoires. The high germline and somatic diversity of the Ig repertoire presents challenges for biologically meaningful analysis, which requires specialized computational methods. We have developed a suite of utilities,(More)
UNLABELLED Driven by dramatic technological improvements, large-scale characterization of lymphocyte receptor repertoires via high-throughput sequencing is now feasible. Although promising, the high germline and somatic diversity, especially of B-cell immunoglobulin repertoires, presents challenges for analysis requiring the development of specialized(More)
Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci(More)
The genes that produce antibodies and the immune receptors expressed on lymphocytes are not germline encoded; rather, they are somatically generated in each developing lymphocyte by a process called V(D)J recombination, which assembles specific, independent gene segments into mature composite genes. The full set of composite genes in an individual at a(More)
The B and T cells of the human adaptive immune system leverage a highly diverse repertoire of antigen-specific receptors to protect the human body from pathogens. The sequencing and analysis of immune repertoires is emerging as an important tool to understand immune responses, whether beneficial or harmful (in the case of autoimmunity). However, methods for(More)
AbVitro Inc., Boston, MA, USA. Current: Juno Therapeutics Inc., 307 Westlake Avenue N, Seattle, WA 98109, USA. International AIDS Vaccine Initiative, New York, NY 10038, USA IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps(More)
Semantic vector models are used to generate high-dimensional vector representations of words from their occurrence statistics across large corpora of electronic text. In these models, the occurrence of a word or number in a particular context is treated as a discrete event, including numerical measurements of continuous properties. In addition, the sequence(More)
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