Jason A Giacomo

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Quantitative assessment of metabolites of drug candidates in early-phase clinical development presents an analytical challenge when methods, standards and assays are not yet available. Radioisotopic labeling, principally with radiocarbon ((14)C), is the preferred method for discovering and quantifying the absolute yields of metabolites in the absence of(More)
Accelerator Mass Spectrometry is an established technology whose essentiality extends beyond simply a better detector for radiolabeled molecules. Attomole sensitivity reduces radioisotope exposures in clinical subjects to the point that no population need be excluded from clinical study. Insights in human physiochemistry are enabled by the quantitative(More)
Accelerator mass spectrometers have an energy acceleration and charge exchange between mass definition stages to destroy molecular isobars and allow single ion counting of long-lived isotopes such as (14)C (t½=5370 years.). 'Low' voltage accelerations to 200 kV allow laboratory-sized accelerator mass spectrometers instruments for bioanalytical quantitation(More)
Here we investigate the effect of lithium iodide and cetyltrimethylammonium (CTA) bromide additives on the ability of LiMo(3)Se(3) nanowire film sensors to bind and detect organic solvents electrically. Both additives decrease the electrical conductivity of the films. Lithium iodide increases the response of the films to both polar and nonpolar analytes.(More)
Thin films of metallic nanowire bundles derived from the Chevrel compound LiMo3Se3 undergo reversible increases of their electrical resistance (up to 70%) upon exposure to vapors of organic solvents (Qi, X. B.; Osterloh, F. E. J. Am. Chem. Soc. 2005, 127 (21), 7666-7667). Using quartz crystal microbalance measurements with four analytes, we demonstrate here(More)
We have prepared Fe.Ni-, multilayers on Cu(l 11) in order to learn how to control the structure and magnetism of these thin alloy films, which are relevant to the giant magnetoresistance (GMR) effect used in magnetic disk drive heads. Using the Spectromicroscopy Facility ( on Undulator Beamline 7.0 at the Advanced Light Source, we have measured(More)
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