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  • D Hickman, Jih Pyang Wang, Yinghong Wang, Jashvant D Unadkat
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1998 (First Publication: 1 March 1998)
  • There is a need for methodology to predict clinically significant drug-drug interactions so that clinical studies can be directed toward interactions which are likely to be clinically relevant. ToContinue Reading
  • Lucy D.N. Sasongko, Jeanne M. Link, +5 authors Jashvant D Unadkat
  • Medicine, Chemistry
  • Clinical pharmacology and therapeutics
  • 2005 (First Publication: 1 June 2005)
  • BACKGROUND Numerous knockout mouse studies have revealed that P-glycoprotein (P-gp) significantly limits drug distribution across the mouse blood-brain barrier (BBB). To determine the importance ofContinue Reading
  • Marek Droździk, Christian Gröer, +7 authors Stefan Oswald
  • Chemistry, Medicine
  • Molecular pharmaceutics
  • 2014 (First Publication: 11 September 2014)
  • Intestinal transporters are crucial determinants in the oral absorption of many drugs. We therefore studied the mRNA expression (N = 33) and absolute protein content (N = 10) of clinically relevantContinue Reading
  • Bhagwat Prasad, Raymond Evers, +5 authors Jashvant D Unadkat
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2014 (First Publication: 1 January 2014)
  • Interindividual variability in protein expression of organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, OATP2B1, and multidrug resistance-linked P-glycoprotein (P-gp) or ABCB1 wasContinue Reading
  • Rajgopal Govindarajan, George Pak Heng Leung, Mingyan Zhou, C Ming Tse, Joanne H. Wang, Jashvant D Unadkat
  • Medicine, Biology
  • American journal of physiology. Gastrointestinal…
  • 2009 (First Publication: 1 April 2009)
  • Human equilibrative nucleoside transporter-3 (hENT3) was recently reported as a pH-dependent, intracellular (lysosomal) transporter capable of transporting anti-human immunodeficiency virus (HIV)Continue Reading
  • Mary F. Hebert, Xiao-Ping Ma, +15 authors Paolo Vicini
  • Medicine
  • Clinical pharmacology and therapeutics
  • 2009 (First Publication: 1 June 2009)
  • Glyburide's pharmacokinetics (PK) and pharmacodynamics have not been studied in women with gestational diabetes mellitus (GDM). The objective of this study was to assess steady-state PK of glyburide,Continue Reading
  • Honggang Wang, Xiaohui Wu, +5 authors Qingcheng Mao
  • Medicine, Biology
  • American journal of physiology. Endocrinology and…
  • 2006 (First Publication: 1 December 2006)
  • The breast cancer resistance protein (BCRP) plays an important role in drug disposition, including limiting drug penetration across the placental barrier. Our goal was to investigate the effects ofContinue Reading