Jaroslav Rácek

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Modification of low density lipoprotein (LDL) particles due to oxidation, glycation and binding of advanced glycation end-products (AGEs) or malondialdehyde (MDA, a final product of lipid peroxidation) is considered most important in the process of atherogenesis. Oxidatively modified LDL are distinguished by another receptor type, which was discovered on(More)
HINTERGRUND: Die Plasmaspiegel des endogenen Stickoxid-Hemmers asymmetrisches Dimethylarginin (ADMA) sind bei chronischem Nierenversagen erhöht und könnten zu den vaskulären Komplikationen beitragen. In dieser Studie wurde die Hypothese überprüft, ob diese erhöhten ADMA-Spiegel bei übergewichtigen CNV-Patienten durch eine Langzeittherapie mit einer(More)
The aim of this study was to determine the effect of chromium (Cr)-enriched yeast on blood glucose and insulin variables, blood lipids, and blood markers of oxidative stress in persons with type 2 diabetes mellitus (median duration: 3.0 yr). Thirty-six subjects (9 men, 27 women; mean age: 61.3 yr; mean body mass index: 34.33 kg/m2) were supplemented with(More)
Oxidative stress is probably a pathophysiological process leading to disadvantageous outcomes in diabetic pregnancies. We aimed to map a complex of potential markers of oxidative stress in this condition. Diabetic mothers had significantly higher concentrations of thiobarbituric acid reactive substances in the plasma [TBARS] both before (p<0.0001) and after(More)
HINTERGRUND: Die Adipositas ist ein Hochrisikofaktor sowohl für die Entwicklung von Gefäßerkrankungen als auch für chronische Niereninsuffizienz (CKD). Ziel dieser Studie ist es, den Einfluss des Fettgewebes auf den Entzündungsstatus bei adipösen Patienten mit CDK zu erfassen. PATIENTEN UND METHODEN: In einer prospektiven Querschnitt-Studie analysierten wir(More)
A recently discussed cardiovascular risk factor, asymmetric dimethylarginine (ADMA), is known to act as an endogenous inhibitor of endothelial nitric oxide synthase. The aim of this study was to establish 1) the relationship between ADMA and ultrasonographically or biochemically determined endothelial dysfunction in children, and 2) the effect of folate(More)
OBJECTIVES (i) to determine the extent of oxidative stress and DNA damage and repair using a panel of selected markers in patients with type 1 and type 2 diabetes mellitus (T1DM, T2DM), (ii) to find their possible relationships with diabetes compensation and duration, and finally (iii) to test for the effect of functional polymorphisms in the 8-oxoguanin(More)
Diabetes mellitus is considered to be one of a rank of free radical diseases. The existence of hyperglycemia produces increased oxidative stress (OS) via non-enzymatic glycation, glucose autoxidation, and alterations in polyol pathway activity with subsequent influences on the whole organism. In childhood, Type 1 diabetes prevails and is characterized by(More)
BACKGROUND Brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are released into circulation as a result of congestive heart failure (HF). As HF and water overload are frequent complications in haemodialysis (HD) patients, we decided to study the levels of BNP and NT-proBNP and their changes during HD. METHODS BNP and NT-proBNP levels were(More)