Jaroslav Kalina

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BACKGROUND Natalizumab (NTZ), a monoclonal antibody to human α4β1/β7 integrin, is an effective therapy for multiple sclerosis (MS), albeit associated with progressive multifocal leukoencephalopathy (PML). Clinicians have been extending the dose of infusions with a hypothesis of reducing PML risk. The aim of the study is to evaluate the clinical consequences(More)
Having IS/ICT processes compliant according to well known standards like COBIT or ITIL is relatively popular especially among larger organizations (to which these standard are primarily aimed). This paper discusses how standardization of processes affects or is affected by a selected set of process characteristics and tries to provide general guidelines(More)
The objective of this study was to describe SymptoMScreen, an in-house developed tool for rapid assessment of MS symptom severity in routine clinical practice, and to validate SymptoMScreen against Performance Scales (PS). MS patients typically experience symptoms in many neurologic domains. A tool that would enable MS patients to efficiently relay their(More)
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