BACKGROUND Natalizumab (NTZ), a monoclonal antibody to human α4β1/β7 integrin, is an effective therapy for multiple sclerosis (MS), albeit associated with progressive multifocal leukoencephalopathy (PML). Clinicians have been extending the dose of infusions with a hypothesis of reducing PML risk. The aim of the study is to evaluate the clinical consequences… (More)
Standard multivariate statistical methods in medical applications are too sensitive to the assumption of multivariate normality and the presence of outliers in the data. This paper is devoted to robust statistical methods. In the context of medical image analysis they allow to solve the tasks of face detection and face recognition in a database of images.… (More)
Having IS/ICT processes compliant according to well known standards like COBIT or ITIL is relatively popular especially among larger organizations (to which these standard are primarily aimed). This paper discusses how standardization of processes affects or is affected by a selected set of process characteristics and tries to provide general guidelines… (More)
The Research Institute on Nutrition and Food Security at the University of Barcelona (INSA-UB) was founded in 2005 by twenty-two research groups from the Faculties of Pharmacy and Food Science; Biology; Chemistry; and Geography and History, as well as other UB-affiliated centers and hospitals [...].
The objective of this study was to describe SymptoMScreen, an in-house developed tool for rapid assessment of MS symptom severity in routine clinical practice, and to validate SymptoMScreen against Performance Scales (PS). MS patients typically experience symptoms in many neurologic domains. A tool that would enable MS patients to efficiently relay their… (More)
This paper provides an explanation of the increasing complexity of corporate IT management as a special case of application of the law of requisite variety. Frequently cited drawback of established frameworks of IT best practices like COBIT and ITIL is their complexity and related difficulty in their implementation. Through the perspective of the law of… (More)