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A series of related polycationic compounds has been screened for potential antitumor activity by the NCI's in vitro testing (one dose primary anticancer assay and the NCI-60 full panel screening). The GI50 values of triazines 3 and 4 are on average 1.9 microM and 2.4 microM, respectively. Furan 8 deserves mention too (1.9 microM). The biological test… (More)
The thio-amide and quaternary amine parts of the title compound, C(6)H(15)N(2)S(+)·Cl(-), are mutually almost perpendicular, the dihedral angle being 80.6 (7)°. The thio-amide group is planar and adopts a Z conformation, whereas the amine end of the cation is in an extended conformation. In the supra-molecular structure, mol-ecules are linked into… (More)
Various agents have been synthesized and proved useful for the National Cancer Institute's anticancer testing as potential new drugs, but most agents suffer side effects from their limited selectivity against cancer cells over healthy ones. Therefore, this paper attempts to describe drugs in terms of the level of tumor cell selectivity which they possess to… (More)
In the title compound, C7H9N3O3, the primary packing motif, viz. an infinite tape, is formed via intermolecular hydrogen bonds of different strengths. In the formation of the tapes, only inversion centres are used; the other symmetry elements of P2(1)/c connect the tapes into a three-dimensional structure through only weak hydrogen bonds.
Mol-ecules of the title compound, C(16)H(8)N(6), lie on crystallographic inversion centres. A dihedral angle of 16.1 (1)° is formed between the central tetra-zine ring and the plane of each cyano-phenyl group. The mol-ecules form stacks along  with a perpendicular inter-planar separation of 3.25 (1) Å. C-H⋯N inter-actions are formed between mol-ecules… (More)
In both 1-(2-cyanoethyl)thymine [systematic name: 3-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanenitrile], C(8)H(9)N(3)O(2), (I), and 1-(3-cyanopropyl)thymine [systematic name: 4-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)butanenitrile], C(9)H(11)N(3)O(2), (II), the core of the supramolecular structure is formed by centrosymmetric… (More)