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The two-allele NcoI Restriction Fragment Length Polymorphism (RFLP) of the TNF alpha region yielding bands of 5.5 and 10.5 kb was investigated in patients with systemic lupus erythematosus (SLE), pauciarticular juvenile rheumatoid arthritis (P-JRA), rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS). In all four disease, we found a decreased(More)
The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation(More)
Thirty patients with acute pancreatitis were allocated to indomethacin suppositories, 50 mg twice daily, or identical-looking placebo suppositories for 7 days in a controlled double-blind trial. The groups of patients were not different with regard to age, sex, etiology, or number of Ranson criteria. The number of days with pain and number of opiate(More)
A routine program for evaluation of the protein pattern in serum and synovial fluid has been tested on 25 patients in a consecutive study. The program comprised agar gel electrophoresis, total protein and albumin determination, and immunochemical determination of antitrypsin, orosomucoid, haptoglobin, IgR, and IgA. Linear correlation analysis of(More)
Following mating of a and alpha isogenic haploids we observe that the frequency of plasmid bearing cells, during selective growth, increases three fold. By examining the mitotic stability, the frequency of plasmid bearing cells during the cell cycle and the copy number of ARS1 plasmids in isogenic haploid and diploid cells, we show that the apparent(More)
The prevalence of antinuclear factors (ANF) found in sera and synovial fluids (SF) of patients with rheumatoid arthritis (RA) varies from one study to another, chiefly according to the technique used. The importance of sensitivity has been emphasized by Ritchie who found ANF in 89% of undiluted RA sera, employing rat liver as nuclear substrate and an(More)