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  • Juha Yrjänheikki, Tero Tikka, Riitta Keinänen, Gundars Goldsteins, Pak Hoo Chan, Jari Koistinaho
  • Medicine
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Publication: 9 November 1999)
  • The only treatment of patients with acute ischemic stroke is thrombolytic therapy, which benefits only a fraction of stroke patients. Both human and experimental studies indicate that ischemic strokeExpand
  • Juha Yrjänheikki, Riitta Keinänen, Milena Pellikka, Tomas G M Hökfelt, Jari Koistinaho
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1998 (First Publication: 22 December 1998)
  • Ischemic stroke is the most common life-threatening neurological disease and has limited therapeutic options. One component of ischemic neuronal death is inflammation. Here we show that doxycyclineExpand
  • Tiina Tikka, Bernd L Fiebich, Gundars Goldsteins, Riitta Keinänen, Jari Koistinaho
  • Medicine, Biology
  • The Journal of Neuroscience
  • 2001 (First Publication: 15 April 2001)
  • Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined whether minocycline reduces excitotoxicity in primary neuronal cultures.Expand
  • Kati H Pulkkinen, Tarja Malm, Mikko P. Turunen, Jari Koistinaho, Seppo Ylä-Herttuala
  • Biology, Medicine
  • FEBS letters
  • 2008 (First Publication: 9 July 2008)
  • Shortage of oxygen is one of the prime stress conditions in tissues. In this study, we looked for microRNAs expressed during hypoxia and showed that miR-210 expression was upregulated in response toExpand
  • Milla Koistinaho, Mikko I. Kettunen, +8 authors Jari Koistinaho
  • Medicine
  • Proceedings of the National Academy of Sciences…
  • 2002
  • beta-amyloid (A beta), derived form the beta-amyloid precursor protein (APP), is important for the pathogenesis of Alzheimer's disease (AD), which is characterized by progressive decline of cognitiveExpand
  • Tarja Malm, Milla Koistinaho, Maria Pärepalo, Tero Vatanen, Jari Koistinaho
  • Biology, Medicine
  • Neurobiology of Disease
  • 2005 (First Publication: 1 February 2005)
  • The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associatedExpand