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Conceptus-derived prostaglandins regulate gene expression in the endometrium prior to pregnancy recognition in ruminants.
In cattle, the blastocyst hatches from the zona pellucida on days 8-9 and then forms a conceptus that grows and elongates into an ovoid and then filamentous shape between days 9 and 16. The growingExpand
Endocrine Delivery of Interferon Tau Protects the Corpus Luteum from Prostaglandin F2 Alpha-Induced Luteolysis in Ewes1
ABSTRACT Paracrine release of ovine interferon tau (oIFNT) from the conceptus alters release of endometrial prostaglandin F2 alpha (PGF) and prevents luteolysis. Endocrine release of oIFNT into theExpand
Pregnancy-associated genes contribute to antiluteolytic mechanisms in ovine corpus luteum.
The hypothesis that ovine luteal gene expression differs due to pregnancy status and day of estrous cycle was tested. RNA was isolated from corpora lutea (CL) on days 12 and 14 of the estrous cycleExpand
Functional Role of Arginine During the Peri-implantation Period of Pregnancy. II. Consequences of Loss of Function of Nitric Oxide Synthase NOS3 mRNA in Ovine Conceptus Trophectoderm1
ABSTRACT Nitric oxide (NO) is a gaseous molecule that regulates angiogenesis and vasodilation via activation of the cGMP pathway. However, functional roles of NO during embryonic development fromExpand
Temporal Release, Paracrine and Endocrine Actions of Ovine Conceptus-Derived Interferon-Tau During Early Pregnancy1
ABSTRACT The antiviral activity of interferon (IFN) increases in uterine vein serum (UVS) during early pregnancy in sheep. This antiviral activity in UVS collected on Day 15 of pregnancy is blockedExpand
Functional Roles of Arginine During the Peri-Implantation Period of Pregnancy. III. Arginine Stimulates Proliferation and Interferon Tau Production by Ovine Trophectoderm Cells via Nitric Oxide and
ABSTRACT In mammal species, arginine is a multifunctional amino acid required for survival, growth, and development of conceptuses (embryo/fetus and associated extraembryonic membranes) during theExpand
Pregnancy-induced changes in metabolome and proteome in ovine uterine flushings†
Abstract Mass spectrometry (MS) approaches were used herein to identify metabolites and proteins in uterine flushings (UF) that may contribute to nourishing the conceptus. Ovine uteri collected onExpand
Endocrine conceptus signaling in ruminants
The corpus luteum (CL) releases progesterone, which acts on the endometrium to induce release of histotroph that supports the free-floating conceptus and prepares for epithelial-chorial placentation.Expand
Corpus Luteum and Early Pregnancy in Ruminants
This review examines the function of the corpus luteum (CL) with emphasis on pregnancy in ruminant models and the possible impact of pregnancy in conferring luteal resistance to prostaglandin F2αExpand