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OBJECTIVE The study of geographic differences in basal metabolic rate (BMR). DESIGN A retrospective analysis of two large BMR databases, namely those of Schofield et al. (1985; Hum. Nutr.: Clin. Nutr. 39C, Suppl. 1, 5-41) and Henry and Rees (1988; Comparative nutrition, pp. 149-159). SUBJECTS The pooled database from the above sources comprised 7737(More)
While advances in network and pathway analysis have flourished in the era of genome-wide association analysis, understanding the genetic mechanism of individual loci on phenotypes is still readily accomplished using genetic modeling approaches. Here, we demonstrate two novel genotype-phenotype models implemented in a flexible genetic modeling platform. The(More)
Previously, we have reported linkage of markers from chromosome 1q22 to schizophrenia, a finding supported by several independent studies. We have now examined the region of strongest linkage for evidence of linkage disequilibrium (LD) in a sample of 24 Canadian familial-schizophrenia pedigrees. Analysis of 14 microsatellites and 15 single-nucleotide(More)
OBJECTIVE The authors previously demonstrated significant association between markers within NOS1AP and schizophrenia in a set of Canadian families of European descent, as well as significantly increased expression in schizophrenia of NOS1AP in unrelated postmortem samples from the dorsolateral prefrontal cortex. In this study the authors sought to apply(More)
Schizophrenia is a serious neuropsychiatric illness estimated to affect approximately 1% of the general population. As part of a genome scan for schizophrenia susceptibility loci, we have previously reported a maximum heterogeneity four-point lod score of 6.50 on chromosome 1q21-22 in a group of 22 medium-sized Canadian families, selected for study because(More)
A review of the studies of basal metabolic rate (BMR) in human subjects migrating between tropical and temperate countries is presented. Such an analysis showed conflicting results of BMR in tropical migrants when expressed as BMR/kg/d. Much of this confusion may be attributable to experimental design and poor selection of subjects. A longitudinal study of(More)
The object of this work was to investigate the constancy of basal metabolic rate (BMR) over time. The BMR was measured in a group of healthy free-living adult men on three separate occasions over some 2 years. Analysis of variance showed that the coefficient of variation within subjects was 4 per cent and between subjects 8 per cent. The results are(More)
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