Jaquelyn L. Jahn

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In the central nervous system, serotonin, an important neurotransmitter and trophic factor, is synthesized by both mast cells and neurons. Mast cells, like other immune cells, are born in the bone marrow and migrate to many tissues. We show that they are resident in the mouse brain throughout development and adulthood. Measurements based on capillary(More)
Gleason grade is universally used for pathologic scoring of the differentiation of prostate cancer. However, it is unknown whether prostate tumors arise well differentiated and then progress to less differentiated forms or if Gleason grade is an early and largely unchanging feature. Prostate-specific antigen (PSA) screening has reduced the proportion of(More)
BACKGROUND Several lifestyle factors have been associated with risk of lethal prostate cancer, but little is known about their combined effect. Our objective was to develop and apply a lifestyle score for prevention of lethal prostate cancer. METHODS We developed a lifestyle score among 42 701 men in the Health Professionals Follow-up Study (HPFS)(More)
It is unknown whether Jim Crow—i.e., legal racial discrimination practiced by 21 US states and the District of Columbia and outlawed by the US Civil Rights Act in 1964—affects US cancer outcomes. We hypothesized that Jim Crow birthplace would be associated with higher risk of estrogen-receptor-negative (ER−) breast tumors among US black, but not white,(More)
I n an elegant analysis from the Atherosclerosis Risk in Communities Study, Rasmussen-Torvik and colleagues demonstrate that a higher degree of adherence to the American Heart Association's 7 health and behavior factors recommended for prevention of cardiovascular disease was also related to substantially reduced incidence of cancer, over a 17-to 19-year(More)
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