Janusz Krassowski

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PURPOSE The study was undertaken to evaluate the frequency of inherited medullary thyroid carcinoma (MTC) among patients with apparent sporadic disease. A stepwise algorithm was used depending on clinical indices and the age of patient at MTC diagnosis. PATIENTS AND METHODS One hundred sixteen patients with MTC verified by postoperative pathologic(More)
Excessive GH response to various stimuli has been frequently described in diabetes mellitus. We studied the GH response to a synthetic GHRH in a group of 16 non-obese Type I diabetic patients. GHRH (1-44) given as iv bolus at a dose of 50 micrograms induced a markedly greater GH response in the diabetic than in the normal subjects with peak values of 39.5(More)
OBJECTIVE Decline in growth hormone (GH) secretion and serum levels of insulin-like growth factor-1 (IGF-1) during ageing may be a causal factor in the development of osteopenia. The purpose of this study was to test the effects of GH-replacement therapy on bone metabolism and mineral density in healthy men over 40 years old. MATERIAL 18 healthy men aged(More)
Ornithine-alpha-ketoglutarate (OAK), a drug commonly used in various catabolic states, was studied for its acute effects on endocrine pancreas. A 30-min infusion of OAK (20 g/m2) induced significant increases in insulin levels (from 15 through 60 min) and in glucagon levels (from 15 through 90 min). However, OAK-induced insulin and glucagon responses were(More)
Glucose tolerance was assessed in 100 cases of adrenocortical hyperfunction (79-Cushing's disease and 21-Cushing's syndrome). Overt diabetes was found in 19 cases. Of the remaining 81 patients 37 had normal glucose tolerance, in 23 glucose tolerance was impaired and in 21 patients diabetes was diagnosed. Glucose tolerance expressed as 60 and 120 min glucose(More)
UNLABELLED The relationship of growth hormone (GH) to the ageing process is currently subject of considerably interest. The study was designed to investigate the effects of replacement therapy with growth hormone on quality of life, serum lipids and body composition (fat free mass and fat mass) in elderly men. MATERIAL 18 healthy men 60.0 +/- 2.4 (x +/-(More)
Characterisation of biogases is normally dedicated to the online monitoring of the major components methane and carbon dioxide and, to a lesser extent, to the determination of ammonia and hydrogen sulphide. For the case of Volatile Organic Compounds (VOCs), much less attention is usually paid, since such compounds are normally removed during gas(More)