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It is well established that generalized epileptiform EEG discharges unaccompanied by overt clinical change may nevertheless be associated with transitory cognitive impairment (TCI) detectable by appropriate psychological testing. However, the tests employed in most research studies of this phenomenon are of little use for routine clinical application. They(More)
Eighteen continuous 48 h monitoring studies are reported from 17 patients with epilepsy. The numbers of epileptiform discharges over corresponding epochs of the 2 days were significantly positively correlated in 16 studies. However, this was explicable by masking due to the sleep/wake cycle and when waking and sleep were considered separately a minority of(More)
The time relations of epileptic events have been studied in 3 sets of data: (I) counts of individual epileptiform discharges in twelve 48 h EEG recordings, (IIa) seizure calendars of 30 therapy-resistant outpatients participating in a drug trial, (IIb) seizure calendars of 10 mentally subnormal epileptic patients resident in a long-stay unit. The EEG data I(More)
A requirement for intensive epilepsy monitoring arose from a demand for ictal EEG registration for diagnostic purposes and in the context of pharmacokinetic research. The monitoring facility developed gradually: first conventional EEG equipment was used on the wards, later miniaturized pre-amplifiers were introduced to allow the patient greater freedom,(More)
A phase 2, open-label study in 21 patients with non-Val30Met and non-Val122Ile hereditary transthyretin amyloidosis showed that tafamidis (20 mg daily for 12 months) stabilized these transthyretin variants. We assessed cardiac amyloid infiltration and cardiac abnormalities in this same study population. At baseline, median age was 64.3 years, 11 patients(More)
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