Janos Polonyi

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Quinolones and coumarins were potent eliminators of chloroplasts from Euglena gracilis. There was a remarkable similarity between antichloroplastic and antibacterial activities of DNA gyrase inhibitors. Quinolones produced 100% chloroplast-free cells in concentrations which do not affect cell viability. Optimal conditions were exponential growth, continuous(More)
The genotoxic effect of ofloxacin was significantly decreased by standard antimutagens (sodium selenite, ascorbic acid, butylated hydroxyanisole and butylated hydroxytoluene) in the unicellular flagellate Euglena gracilis. The antiofloxacin activity of sodium selenite was also documented by a bacterial test in which the repair-proficient strain Salmonella(More)
A c-number path integral representation is constructed for the solution of the Dirac equation. The integration is over the real trajectories in the continuous three-space and other two canonical pairs of compact variables controlling the spin and the chirality flips. The path integral representation of the quantum amplitudes [1] has become an essential(More)
Renormalization group flow equations for scalar λΦ are generated using three classes of smooth smearing functions. Numerical results for the critical exponent ν in three dimensions are calculated by means of a truncated series expansion of the blocked potential. We demonstrate how the convergence of ν as a function of the order of truncation can be improved(More)
The mutagenicity (bleaching activity) of ofloxacin (43 microM) and acridine orange (AO) (13.5 microM) in Euglena gracilis is inhibited by plant phenolics. Caffeic acid (CA), p-coumaric acid (PCA), ferulic acid (FA) and gentisic acid (GA) (25, 50, 100 and 250 microM) exhibited a significant concentration-dependent inhibitory effect against ofloxacin-induced(More)
The antimutagenicity of 14 naturally occurring flavonoids (20 mumol/l) on ofloxacin (43 mumol/l and 86 mumol/l)-induced bleaching (mutagenicity) was studied in Euglena gracilis. The flavonoids chrysin, techtochrysin, chrysin-5-methylether galangin, galangin-5-methylether, pinocembrin and pinobanksin possess considerable antimutagenic properties against(More)
Inhibitory activity of tetracycline against ofloxacin- and fleroxacin-induced bleaching of green and etiolated Euglena gracilis was examined. Tetracycline hydrochloride in concentrations of 83-2079 microM in the light partially inhibited the bleaching activity of 83 microM ofloxacin and of 162 microM fleroxacin. In the dark, the TC inhibition of the(More)
Euglena gracilis cells were treated with N-succinimidylofloxacin. After two years of cultivation of chloroplast-free mutants a number of anomalous mitochondria have been observed. Aberrant mitochondria about 5–8 μm long and wide with unusual shape, disfigured mitochondria with enormous size, giant swollen oval-shaped megamitochondria, narrow and very long(More)
The inhibitory activity of lignin against nitrosoguanidine (MNNG)- and acridine orange (AO)- induced mutagenesis was examined using two microbial systems: green unicellular flagellate Euglena gracilis and Salmonella typhimurium TA100 and TA97. To verify the hypothesis that the above mentioned mutagens may generate some oxidant species and subsequently free(More)
To verify the hypothesis that the fluoroquinolone inhibitors of DNA gyrase generate some oxidant species and subsequently free radicals, the effects of simultaneous action of fluoroquinolones (ofloxacin, fleroxacin) and tetracyclines (tetracycline, doxycycline, thiatetracycline) or cetylpyridinium bromide as possible antioxidants on the flagellate Euglena(More)