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OBJECTIVE To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. DESIGN A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. SETTING Review of PubMed, Web of Science, and Embase for papers about(More)
OBJECTIVE To investigate whether first trimester exposure to lamotrigine (LTG) monotherapy is specifically associated with an increased risk of orofacial clefts (OCs) relative to other malformations, in response to a signal regarding increased OC risk. METHODS Population-based case-control study with malformed controls based on EUROCAT congenital anomaly(More)
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