Janneke Jentink

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BACKGROUND The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited. METHODS We first combined data from eight published cohort studies (1565 pregnancies in which the women were exposed to valproic acid, among which 118 major(More)
OBJECTIVE To compare the prescription of drugs in women over a period from 2 years before until 3 months after pregnancy, regarding the type of drugs used and the fetal risk. DESIGN A cohort study based on pharmacy records of women giving birth to a child between 1994 and 2003. SETTING The study was performed with data from the InterAction database,(More)
OBJECTIVE To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. DESIGN A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. SETTING Review of PubMed, Web of Science, and Embase for papers about(More)
OBJECTIVE To investigate whether first trimester exposure to lamotrigine (LTG) monotherapy is specifically associated with an increased risk of orofacial clefts (OCs) relative to other malformations, in response to a signal regarding increased OC risk. METHODS Population-based case-control study with malformed controls based on EUROCAT congenital anomaly(More)
PURPOSE Women with child wish are advised to take folic acid supplements to reduce the risk for spina bifida. However, there is less evidence for this protective effect in women using valproic acid (VPA). We investigated the effect of folic acid in women exposed to VPA in the first trimester of pregnancy. METHODS A case-control study was performed with(More)
OBJECTIVE To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-α (TNF-α) antagonist and the general population. METHODS Analysis for comparison of proportional differences to a(More)
BACKGROUND Folic acid intake before and during pregnancy reduces neural tube defects (NTD). Therefore, several countries have enriched bulk food with folic acid resulting in a 26-48% decrease in the prevalence of NTDs. In 2000, the Dutch Health Council advised against folic acid enrichment based on literature research; yet formal cost-effectiveness(More)
BACKGROUND Anti-epileptic drugs are known to be teratogenic, yet many women do need to continue the anti-epileptic drug use during pregnancy. OBJECTIVES To perform an economic evaluation of the anti-epileptic drug choice in young women who potentially wish to become pregnant. In particular, to estimate the impact of teratogenicity on the costs per quality(More)
PURPOSE A case-control study is the most powerful design to test the risk of specific congenital malformations associated with a specific drug. However, malformation registries often lack non-malformed controls. For the Dutch EUROCAT, we collected a non-malformed control group: the 'Healthy Pregnant'. The aim of this study was to evaluate the(More)
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