Janka Vašková

Learn More
Humic acids are known for their overall positive health and productivity effects in animal feeding trials and, controversially, as an aetiological factor of cancer. We tried to assess the in vitro effect of humic acids from a selected source in Slovakia when used at recommended prophylactic dosage. We investigated antioxidant properties, enzymatic and(More)
The aim of the study was to investigate the anti-proliferative activity of brassinin and its derivatives on human cancer cell lines. We found that among twenty-one tested compounds, 1- methoxybrassinin exerted the most potent anti-proliferative activity in Caco-2 cells with IC₅₀ 8.2 (±1.2)μmoll(-1). The flow cytometric analysis revealed a(More)
Phenolic compounds from plants are known for their antioxidant properties and have been proposed as therapeutic agents to counteract oxidative stress. However, under normal circumstances, the body only receives a very small amount of these substances in the diet. We have investigated the effect of extracts from known and frequently used plants as part of(More)
OBJECTIVES The objective of this paper is to highlight the selected group of patients in which adjuvant therapy seems to have a more pronounced positive effect. DESIGN AND METHODS 65 septic patients from the prospective observational study Se-AOX (2008-2012) (ClinicalTrials.gov Identifier: NCT02026856) were divided into a Se group, receiving sodium(More)
Metal-containing drugs have long been used for medicinal purposes in more or less empirical way. The potential of these anticancer agents has only been fully realised and explored since the discovery of the biological activity of cisplatin. Cisplatin and carboplatin have been two of the most successful anti-cancer agents ever developed, and are currently(More)
OBJECTIVE Antioxidant, anti-inflammatory and venoconstrictor properties have been attributed to extracts from Aesculus hippocastanum. These unusual and diverse properties may be possibly basically linked with ability to scavenge free radicals. MATERIALS AND METHODS The scavenging capacity of dry horse chestnut extract of and escin have been investigated(More)
BACKGROUND In this work, we evaluated the incidence and prognostic value of several genetic aberrations in patients with a diagnosis of acute myeloid leukemia (AML). PATIENTS AND METHODS We analysed 90 patients: 42 males (mean age 54.5 years) and 48 females (mean age 59 years), with AML. The genetics of all leukemia samples was studied using conventional(More)
An epidemiological investigation revealed a high incidence of structural disorders of dental tissues in the child population of Prague. While hypoplastic disorders are steadily diminishing, there is an ever rising trend of hypomineralization. The observed disorders of hypomineralization are becoming a serious clinical problem. The aim of the present(More)
BACKGROUND Serious intraabdominal infections belong among life treating diseases. They are based on spreading infections from focal sources of inflammation in abdomen or damaged intestinal wall. METHODS AND RESULTS Treatment strategies are surgical intervention, antimicrobial therapy, distributional shock treatment and accurate nutritional support (1).(More)