Janis M. Yee

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DNA damage slows DNA synthesis at replication forks; however, the mechanisms remain unclear. Cdc7 kinase is required for replication origin activation, is a target of the intra-S checkpoint, and is implicated in the response to replication fork stress. Remarkably, we found that replication forks proceed more rapidly in cells lacking Cdc7 function than in(More)
Vigabatrin (gamma-vinyl GABA) is an antiepileptic drug and blocks GABA transaminase activity resulting in elevations in cellular GABA levels in the brain. Nipecotic acid (NPA) promotes release of GABA from neonatal optic nerve astrocytes, resulting in a bicuculline-sensitive depolarization of the optic nerve axons. The NPA-induced depolarization of(More)
With the routine use of sonography in the evaluation of patients with pelvic masses, it is essential to be familiar with the sonographic features of fallopian tube carcinoma so that diagnosis can be made early and thus contribute to prompt management of these patients. The authors present the clinical manifestations, sonographic features, and pathologic(More)
Sonographic examination of the abdomen was performed in 155 patients with clinical diagnosis of AIDS. Approximately one half of the patients had hyperechoic (fatty) liver and splenomegaly. About one third of the patients had lymphadenopathy and hyperechoic kidneys. Intravenous drug abusers were more likely to have renal parenchymal changes, whereas patients(More)
Because of frequent failures in nonoperative therapy, we have adopted early surgical drainage of the pericardium in the management of uremic pericardial effusion. This series presents the longest follow-up period of any group of patients with uremic pericardial effusion treated by surgical drainage. There have been no intraoperative deaths and no(More)
The functional response is the most basic form of the predator-prey interaction. There are three main response types: a linear rise in prey consumption with increasing prey densities to a plateau (type I), a decelerating curvilinear rise to a plateau (type II), or a sigmoidal shaped curve (type III). Type III responses have been shown to allow for long-term(More)