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  • Janice K. Laramy, Minjee Kim, +8 authors William F Elmquist
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 November 2017
  • This study investigated how differences in drug distribution and free fraction at different tumor and tissue sites influence the efficacy of the multikinase inhibitor ponatinib in a patient-derivedContinue Reading
  • Minjee Kim, Janice K. Laramy, +4 authors William F Elmquist
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 April 2019
  • Tyrosine kinase inhibitors that target the epidermal growth factor receptor (EGFR) have had success in treating EGFR-positive tumors, including non-small-cell lung cancer (NSCLC). However, developingContinue Reading
  • Janice K. Laramy, Minjee Kim, Karen E. Parrish, Jann N Sarkaria, William F Elmquist
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 May 2018
  • A compartmental blood-brain barrier (BBB) model describing drug transport across the BBB was implemented to evaluate the influence of efflux transporters on the rate and extent of the multikinaseContinue Reading
  • Jann N Sarkaria, David Calligaris, +11 authors William F Elmquist
  • Medicine
  • 15 August 2016
  • Clinical data indicate that certain regions within glioblastoma (GBM) have a relatively intact blood-brain barrier (BBB), but controversy surrounds whether associated heterogeneous delivery may limitContinue Reading