Janice E. Chang

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The purpose of this study was to determine the prevalence of BRCA1 mutations in Chinese breast cancer patients in Singapore. BRCA1 analysis was conducted in consecutive patients with breast cancer before the age of 40 years (76 women), or whose relatives had breast or ovarian cancer (16 women). Ten patients had both early onset breast cancer and affected(More)
Speech perception in the presence of another competing voice is one of the most challenging tasks for cochlear implant users. Several studies have shown that (1) the fundamental frequency (F0) is a useful cue for segregating competing speech sounds and (2) the F0 is better represented by the temporal fine structure than by the temporal envelope. However,(More)
OBJECTIVES/HYPOTHESIS To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea. STUDY DESIGN Ex vivo, porcine model. METHODS Optical coherence tomographic images of the porcine cochlea were obtained by thinning the bone from the basal turn of the cochlea leaving the endosteum intact. The images(More)
A cochlear implant (CI) signal processing strategy named F0 modulation (F0mod) was compared with the advanced combination encoder (ACE) strategy in a group of four post-lingually deafened Mandarin Chinese speaking CI listeners. F0 provides an enhanced temporal pitch cue by amplitude modulating the multichannel electrical stimulation pattern at the(More)
Speech can be recognized by multiple acoustic cues in both frequency and time domains. These acoustic cues are often thought to be redundant. One example is the low-frequency sound component below 300 Hz, which is not even transmitted by the majority of communication devices including telephones. Here, we showed that this low-frequency sound component,(More)
Experimental conditions were defined that determined the synthesis of dextran-hemoglobin complexes through the alklation of hemoglobin by N-bromoacetylaminoethylaminodextran. Using appropriate concentrations of the two reactants, over 90% yield of dextran-hemoglobin was obtained for dextrans of average molecular weight of 200 000 110000, 70000, 400000, and(More)
Electric stimulation of the auditory nerve via a cochlear implant (CI) has been observed to suppress tinnitus, but parameters of an effective electric stimulus remain unexplored. Here we used CI research processors to systematically vary pulse rate, electrode place, and current amplitude of electric stimuli, and measure their effects on tinnitus loudness(More)
OBJECTIVE To systematically evaluate the noise generated by toys targeted for children and to compare the results over the course of 4 consecutive holiday shopping seasons. STUDY DESIGN Experimental study. SETTING Academic medical center. SUBJECTS AND METHODS During 2008-2011, more than 200 toys marketed for children older than 6 months were screened(More)
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