Learn More
BACKGROUND Chronic traumatic encephalopathy (CTE) is the term coined for the neurodegenerative disease often suspected in athletes with histories of repeated concussion and progressive dementia. Histologically, CTE is defined as a tauopathy with a distribution of tau-positive neurofibrillary tangles (NFTs) that is distinct from other tauopathies, and(More)
We review the relationship between traumatic brain injury (TBI) and the development of idiopathic Parkinson's disease (PD) or secondary parkinsonism. Limited by methodological issues such as recall bias and confounding risk factors, epidemiological studies on the association between TBI and idiopathic PD have so far yielded mixed results. While clinical(More)
Cerebral hyaline astrocytic inclusions have been observed in a subset of patients with early onset epilepsy, brain structural anomalies, and developmental delay, which indicates that it may represent a unique clinicopathologic entity. To further characterize this condition we use proteomics to investigate differentially expressed proteins in epileptic brain(More)
Leukocytes arrested on inflamed endothelium via integrins are subjected to force imparted by flowing blood. How leukocytes respond to this force and resist detachment is poorly understood. Live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upstream α4β1 integrin adhesion sites and the adjacent cortical(More)
Deferoxamine (DFO) has shown therapeutic promise for the treatment of Parkinson׳s disease (PD) as it has reduced both behavioral and biochemical deficits when injected into the brain of rodent models of PD. Intranasally administered DFO targets the brain directly but non-invasively and has been effective in animal models of stroke and Alzheimer׳s disease.(More)
OBJECTIVE To examine risk factors for REM sleep behavior disorder (RBD) in a large-scale community-based study. METHODS This community-based study included 12,784 Chinese adults (10,556 men and 2,228 women, aged 24 years or older) who were free of Parkinson disease and dementia in 2012. Probable RBD (pRBD) status was determined by a validated(More)
BACKGROUND Distancing (i.e. construing oneself as dissimilar to a negatively-stereotyped group) preserves self-esteem and may benefit other domains of subjective well-being. Head and neck cancer (HNC) is stigmatized because major risk factors include avoidable lifestyle variables (smoking, alcohol consumption, and human papilloma virus). Because the(More)
We report a patient with fulminant brainstem demy-elinating disease in the context of previously treated myelodysplastic syndrome (MDS). We hypothesize that autoimmunity associated with MDS can underlie demyelinating syndromes. Clinical case. A 64-year-old man with relapsing polychondritis in remission and stable MDS (diagnosed 1.5 years ago, maintained on(More)
BACKGROUND We describe trends in participation by investigators from low- and middle-income countries (LMCs) in publications describing oncology randomized control trials (RCTs) over a decade. METHODS We used Medline to identify RCTs published in English from 1998 to 2008 evaluating treatment in lung, breast, colorectal, stomach and liver cancers. Data on(More)