Janet R. Roberts

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We present a new data structure for maintaining a set of records in a linear list according to their key values. This data structure has the property that we can keep a number of <italic>fingers</italic> at points of interest in the key space (e.g., the beginning or the end of the list), so that access and modification in the neighborhood of a finger is(More)
We compared peri-prosthetic bone mineral density between identical cemented and cementless LCS rotating platform total knee arthroplasties. Two matched cohorts had dual energy x-ray absorptiometry scans two years post-operatively using a modified validated densitometric analysis protocol, to assess peri-prosthetic bone mineral density. The knee that was not(More)
BACKGROUND Prompt injection of epinephrine is the cornerstone of systemic anaphylaxis treatment. The rate of epinephrine absorption has not been reported previously in allergic children. OBJECTIVE Our objective was to study the clinical pharmacology of epinephrine in this population. METHODS We performed a prospective, randomized, blinded,(More)
There are few objective studies of the benefit/risk ratio of H1-receptor antagonists in children. We hypothesized that terfenadine would provide as effective peripheral H1 blockade as chlorpheniramine in young patients, but would cause less central nervous system dysfunction. We tested this hypothesis with epicutaneous histamine tests to monitor peripheral(More)
Although older, potentially sedating, "first-generation" antihistamines (H1-receptor antagonists) are commonly used in childhood, their central nervous system (CNS) effects have not been well-documented in young subjects. We hypothesized that diphenhydramine and hydroxyzine would affect CNS function adversely in this population. Our objective was to(More)
Twenty patients with asthma (mean age, 10.9 +/- 2 years) entered a six-week, randomized, double-blind, crossover comparison of sustained-release (S-R) terbutaline sulfate (Bricanyl Durules) vs S-R theophylline (Theo-Dur). In each two-week study period each patient received S-R theophylline twice daily in doses previously adjusted to give serum theophylline(More)
BACKGROUND Children with allergic rhinitis may have difficulty with self-assessment of nasal symptoms. OBJECTIVE To correlate objective and subjective assessments of nasal stuffiness in children with seasonal allergic rhinitis. METHODS Children, aged 6 to 12 years, with seasonal allergic rhinitis recorded their degree of nasal obstruction on two(More)
BACKGROUND Brompheniramine has been widely used in the treatment of allergic rhinitis and other disorders during the past 4 decades. There are no published studies of its clinical pharmacology in children. OBJECTIVES This study was performed to test the hypothesis that brompheniramine would have a prompt onset of action and a 24-hour duration of action in(More)
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