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The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1--repetitive sensory motor actions and Factor(More)
We report the identification of a new locus for autosomal dominant limb-girdle muscular dystrophy (LGMD1) on 7q. Two of five families (1047 and 1701) demonstrate evidence in favor of linkage to this region. The maximum two-point LOD score for family 1047 was 3.76 for D7S427, and that for family 1701 was 2.63 for D7S3058. Flanking markers place the LGMD1(More)
Four genes affecting Alzheimer's Disease (AD)(AP, PS1, PS2, and APOE) have been identified and a fifth potential gene localized to chromosome 12. Collectively, these genes explain at most half of the genetic effect in AD. Understanding the genetics of AD is critical to developing new treatments. The quest to find the remaining AD genes led us to undertake a(More)
OBJECTIVE Evaluating a randomized controlled trial involving a tailored behavioral intervention conducted to improve blood pressure control. METHODS Adults with hypertension from two outpatient primary care clinics were randomly allocated to receive a nurse-administered behavioral intervention or usual care. In this ongoing study, patients receive the(More)
OBJECTIVE Non-steroidal anti-inflammatory drugs (NSAIDs) have been consistently associated with reduced colon cancer risk. Associations with other cancer sites, particularly breast cancer, have been less consistent. This study's objective was to examine the relationship between use of non-prescription and prescription NSAIDs and breast cancer and carcinoma(More)
BACKGROUND Administrative procedure code data can estimate colonoscopy utilization; however, determining colonoscopy indication is more difficult as procedure codes do not inherently reflect the purpose (screening, surveillance, diagnosis) of the colonoscopy. AIM To improve the reported sensitivity (70%) and specificity (72%) of a published algorithm for(More)
BACKGROUND To determine which of 3 interventions was most effective in improving blood pressure (BP) control, we performed a 4-arm randomized trial with 18-month follow-up at the primary care clinics at a Veterans Affairs Medical Center. METHODS Eligible patients were randomized to either usual care or 1 of 3 telephone-based intervention groups: (1)(More)
BACKGROUND Experimental studies in animals have suggested that antidepressants may promote the growth of mammary tumors, but epidemiologic data have not shown consistent associations between antidepressant use and breast cancer. METHODS We analyzed data from a population-based, case-control study conducted in North Carolina from 1996 to 2000 to examine(More)
OBJECTIVE We examined the clinical utility of supplementing type 2 diabetes mellitus (DM) risk counseling with DM genetic test results and counseling. RESEARCH DESIGN AND METHODS In this randomized controlled trial, non-diabetic overweight/obese veteran outpatients aged 21 to 65 years received DM risk estimates for lifetime risk, family history, and(More)