Janet M. Grubber

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The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1--repetitive sensory motor actions and Factor(More)
The mouse short ear gene is required for normal growth and patterning of skeletal structures, and for repair of bone fractures in adults. We have carried out an extensive chromosome walk in the chromosome region that surrounds this locus. Here we show that the short ear region contains the gene for a TGF beta-related protein called bone morphogenetic(More)
We report the identification of a new locus for autosomal dominant limb-girdle muscular dystrophy (LGMD1) on 7q. Two of five families (1047 and 1701) demonstrate evidence in favor of linkage to this region. The maximum two-point LOD score for family 1047 was 3.76 for D7S427, and that for family 1701 was 2.63 for D7S3058. Flanking markers place the LGMD1(More)
Four genes affecting Alzheimer's Disease (AD)(AP, PS1, PS2, and APOE) have been identified and a fifth potential gene localized to chromosome 12. Collectively, these genes explain at most half of the genetic effect in AD. Understanding the genetics of AD is critical to developing new treatments. The quest to find the remaining AD genes led us to undertake a(More)
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) have been consistently associated with reduced colon cancer risk. Associations with other cancer sites, particularly breast cancer, have been less consistent. This study's objective was to examine the relationship between use of non-prescription and prescription NSAIDs and breast cancer and carcinoma(More)
BACKGROUND Experimental studies in animals have suggested that antidepressants may promote the growth of mammary tumors, but epidemiologic data have not shown consistent associations between antidepressant use and breast cancer. METHODS We analyzed data from a population-based, case-control study conducted in North Carolina from 1996 to 2000 to examine(More)
BACKGROUND Cardiovascular disease (CVD) and diabetes account for one-third of the mortality difference between African American and white patients. We evaluated the effect of a CVD risk reduction intervention in African Americans with diabetes. METHODS We randomized 359 African Americans with type 2 diabetes to receive usual care or a nurse telephone(More)
The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately(More)
BACKGROUND Fewer than 40% of persons with hypertension in the United States have adequate blood pressure (BP) control. OBJECTIVE To compare 2 self-management interventions for improving BP control among hypertensive patients. DESIGN A 2 x 2 randomized trial, stratified by enrollment site and patient health literacy status, with 2-year follow-up.(More)