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OBJECTIVE Accurate information about the magnitude and distribution of diabetes can inform policy and support health care evaluation. We linked physician service claims (PSCs) and hospital discharge abstracts (HDAs) to determine diabetes prevalence and incidence. RESEARCH DESIGN AND METHODS A retrospective cohort was constructed using administrative data(More)
BACKGROUND The prevalence of diabetes has been increasing greatly, but WHO's predicted 39% rise in the global rate of diabetes from 2000 to 2030 might be an underestimate. We aimed to assess diabetes trends in Ontario, Canada. METHODS Using population-based data, including a validated diabetes database from the province of Ontario, Canada, we examined(More)
OBJECTIVE In vitro evidence shows that immune function is compromised in people with diabetes. Although certain rare infections are more common and infection-related mortality is higher, the risk of acquiring an infectious disease for diabetic patients has never been quantified. RESEARCH DESIGN AND METHODS A retrospective cohort study using administrative(More)
BACKGROUND It is generally appreciated that gestational diabetes is a risk factor for type 2 diabetes. However, the precise relation between these 2 conditions remains unknown. We sought to determine the incidence of diabetes mellitus after diagnosis of gestational diabetes. METHODS We used a population-based database to identify all deliveries in the(More)
Purpose It has been suggested that type 2 diabetes may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The purpose of this study was to examine the impact of diabetes on survival following breast cancer. Methods Using population-based health databases(More)
BACKGROUND Acute diabetic emergencies are potentially avoidable or amenable to timely and effective outpatient therapy. OBJECTIVE To evaluate the relationship between socioeconomic status (SES) and acute complications of diabetes mellitus in Ontario. METHODS We used a population-based cohort of persons with diabetes mellitus (N = 605 825) derived from(More)
BACKGROUND Although epidural anaesthesia and analgesia have numerous benefits, their effects on postoperative survival are unclear. We therefore undertook a population-based cohort study to determine whether perioperative epidural anaesthesia or analgesia is associated with improved 30-day survival. METHODS We used population-based linked administrative(More)
OBJECTIVE To determine whether adjusting for confounder bias in observational studies using propensity scores gives different results than using traditional regression modeling. METHODS Medline and Embase were used to identify studies that described at least one association between an exposure and an outcome using both traditional regression and(More)
OBJECTIVE To compare the risk of acute myocardial infarction, heart failure, and death in patients with type 2 diabetes treated with rosiglitazone and pioglitazone. DESIGN Retrospective cohort study. SETTING Ontario, Canada. PARTICIPANTS Outpatients aged 66 years and older who were started on rosiglitazone or pioglitazone between 1 April 2002 and 31(More)
Clinical researchers frequently assess the statistical significance of the difference between two means by examining whether the two 95% confidence intervals overlap. The purpose of this brief communication is to illustrate that the 95% confidence intervals for two means can overlap and yet the two means can be statistically significantly different from one(More)