Janet D. Cragan

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In recent years, prenatal diagnosis and elective pregnancy termination have affected the reported birth prevalence of trisomies 13 and 18. We examined the prevalence and characteristics of these conditions using 1994-2003 data from a population-based surveillance system, the Metropolitan Atlanta Congenital Defects Program. Including fetal deaths and(More)
OBJECTIVES In this study we used a population-based approach to assess the impact of fetal echocardiography on a well defined birth population with nearly complete ascertainment of cardiac defects. BACKGROUND Although fetal echocardiography is being used more frequently in the prenatal diagnosis of congenital cardiac malformations, its impact on the(More)
OBJECTIVE Encephalocele is classified as a neural tube defect, but questions have been raised regarding whether its epidemiological characteristics are similar to those of other neural tube defects. DESIGN We compared characteristics of temporal trends in, and the impact of folic acid grain fortification on, the prevalence of encephalocele, spina bifida,(More)
BACKGROUND As part of the surveillance program to monitor the occurrence of birth defects in the metropolitan Atlanta area, we developed a record linkage software tool that provides latitude in the choice of linkage parameters, allows for efficient and accurate linkages, and enables objective assessments of the quality of the linked data. METHODS We(More)
Given that half of U.S. pregnancies are unintended and some prescription drugs are frequently used by reproductive-age women, there is an increasing interest in establishing pregnancy registries to monitor fetal exposures and pregnancy outcomes. Physicians report prenatal exposures and pregnancy outcomes, including birth defects, to these registries. We(More)
A fine-grained record integration and linkage tool (FRIL) is presented. The tool extends traditional record linkage tools with a richer set of parameters. Users may systematically and iteratively explore the optimal combination of parameter values to enhance linking performance and accuracy. Results of linking a birth defects monitoring program and birth(More)
We aimed to assess the frequency of chromosomal abnormalities among infants with congenital heart defects (CHDs) in an analysis of population-based surveillance data. We reviewed data from the Metropolitan Atlanta Congenital Defects Program, a population-based birth-defects surveillance system, to assess the frequency of chromosomal abnormalities among(More)
CDC has developed interim guidelines for health care providers in the United States who are caring for infants born to mothers who traveled to or resided in an area with Zika virus transmission during pregnancy. These guidelines include recommendations for the testing and management of these infants. Guidance is subject to change as more information becomes(More)
Methylene blue (MB) is a cationic thiazine dye with the chemical name tetramethylthionine chloride. It has a characteristic deep blue color in the oxidized state, but the reduced form, leukomethylene blue (LMB), is colorless. Methylene blue has been widely used in a variety of clinical settings to identify anatomic (Manhes et al., ’94; Sills and Zinkham,(More)