Janet Cohen Sherman

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A central aspect of the cerebellar cognitive affective syndrome is the dysregulation of affect that occurs when lesions involve the ‘limbic cerebellum’ (vermis and fastigial nucleus). In this case series we describe neuropsychiatric disturbances in adults and children with congenital lesions including cerebellar agenesis, dysplasia, and hypoplasia, and(More)
BACKGROUND In this prospective study, the authors evaluated potential treatment toxicity and progression-free survival in patients with low-grade glioma who received treatment with proton radiation therapy. METHODS Twenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy were enrolled in a prospective,(More)
A 32-year-old woman was seen in the neurogenetics clinic at this hospital because of seizures and cognitive decline. Absence seizures (staring spells) had reportedly begun when the patient was approximately 5 years of age, and atonic seizures (sudden loss of muscle tone resulting in dropping of the head and falling to the floor) had begun during(More)
With the recent publication of new criteria for the diagnosis of preclinical Alzheimer's disease (AD), there is a need for neuropsychological tools that take premorbid functioning into account in order to detect subtle cognitive decline. Using demographic adjustments is one method for increasing the sensitivity of commonly used measures. We sought to(More)
This article concerns how the orientations of objects are represented in the human brain. We propose a coordinate-system hypothesis of orientation representation (COR) and show that the hypothesis provides an explicit basis for interpreting orientation errors. Next, we report results from three studies of individuals with developmental deficits in the(More)
Emotion attribution (EA) from faces is key to social cognition, and deficits in perception of emotions from faces underlie neuropsychiatric disorders in which cerebellar pathology is reported. Here, we test the hypothesis that the cerebellum contributes to social cognition through EA from faces. We examined 57 patients with cerebellar disorders and 57(More)
OBJECTIVE To determine neurocognitive function in HIV-infected subjects with low weight and weight loss. DESIGN Cross-sectional cohort. METHODS Baseline data from male and female participants in longitudinal treatment studies of AIDS wasting were analyzed. Fifty-seven HIV-infected women (age: 38 +/- 5 years, education level: 12.3 +/- 2.3 years) and 24(More)
Cerebellar lesions can cause motor deficits and/or the cerebellar cognitive affective syndrome (CCAS; Schmahmann's syndrome). We used voxel-based lesion-symptom mapping to test the hypothesis that the cerebellar motor syndrome results from anterior lobe damage whereas lesions in the posterolateral cerebellum produce the CCAS. Eighteen patients with isolated(More)
Dr. Roy N. Alcalay (Neurology): A 65-year-old right-handed man was transferred to this hospital because of confusion and memory loss. He had been well until approximately 4 weeks before admission, when he began to have decreased energy and a change in mood. He told his family that he felt as if he was “living in a fog.” Three weeks before admission, he lost(More)