Janet C. Siebert

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Phase 1 study of stereotactic body radiotherapy and interleukin-2--tumor and immunological responses.

Steven K. Seung, Brendan D. Curti, +8 authors Walter J. Urba
Science translational medicine
2012

Preclinical models suggest that focal high-dose radiation can make tumors more immunogenic. We performed a pilot study of stereotactic body radiation therapy (SBRT) followed by high-dose… (More)

Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates.

Julie M Yabu, Janet C. Siebert, Holden T. Maecker
PloS one
2016

BACKGROUND Kidney transplantation is the most effective treatment for end-stage kidney disease. Sensitization, the formation of human leukocyte antigen (HLA) antibodies, remains a major barrier to… (More)

Dominant suppression of Addison's disease associated with HLA-B15.

Peter R. Baker, Erin E. Baschal, +9 authors George S. Eisenbarth
The Journal of clinical endocrinology and…
2011

CONTEXT Autoimmune Addison's disease (AD) is the major cause of primary adrenal failure in developed nations. Autoantibodies to 21-hydroxylase (21OH-AA) are associated with increased risk of… (More)

Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy

Carole L. Galligan, Janet C. Siebert, +4 authors Eleanor N Fish
PloS one
2009

BACKGROUND The precise mechanisms involved in the initiation and progression of rheumatoid arthritis (RA) are not known. Early stages of RA often have non-specific symptoms, delaying diagnosis and… (More)

An analytical workflow for investigating cytokine profiles.

Janet C. Siebert, Margaret S. Inokuma, +6 authors Holden T. Maecker
Cytometry. Part A : the journal of the…
2008

Understanding cytokine profiles of disease states has provided researchers with great insight into immunologic signaling associated with disease onset and progression, affording opportunities for… (More)

Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy.

Benedetto Farsaci, Renee Nicole Donahue, +9 authors Jeffrey Schlom
Cancer immunology research
2016

Tumor immunoscore analyses, especially for primary colorectal cancer and melanoma lesions, provide valuable prognostic information. Metastatic lesions of many carcinoma types, however, are often not… (More)

Systematic evaluation of immune regulation and modulation

David F Stroncek, Lisa H Butterfield, +12 authors Barbara Seliger
Journal for immunotherapy of cancer
2017

Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant… (More)

Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's disease.

Peter R. Baker, Erin E. Baschal, +9 authors George S. Eisenbarth
The Journal of clinical endocrinology and…
2010

CONTEXT Multiple autoimmune disorders (e.g. Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage… (More)

Monitoring cytokine profiles during immunotherapy.

Janet C. Siebert, Edwin B Walker
Immunotherapy
2010

Measuring cytokine production is an integral part of measuring immune response during immunotherapy. Current technologies allow the simultaneous quantification of multiple cytokines in a variety of… (More)

Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex.

Erin E. Baschal, Suparna A. Sarkar, +9 authors George S. Eisenbarth
Journal of diabetes
2011

BACKGROUND We recently reported an association between Type 1 diabetes and the telomeric major histocompatibility complex (MHC) single nucleotide polymorphism (SNP) rs1233478. As further families… (More)

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