Janet C. Cole

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Traveling across time zones causes disruption to the normal circadian rhythms and social schedules because of travelers' shift in time. As the endogenous circadian timing system adapts slowly to new time cues, the phase relationship between biological rhythms and external time cues are out of synchronization for a period of time. This disturbance of(More)
We have used a sensitive activity-dependent probe, sulforhodamine 101 (SR101), to view endocytic events within snake motor nerve terminals. After very brief neural stimulation at reduced temperature, SR101 is visualized exclusively at punctate sites located just inside the presynaptic membrane of each terminal bouton. The number of sites (approximately 26(More)
To investigate the role of actin in vertebrate nerve terminals, nerve-muscle preparations from garter snake (Thamnophis sirtalis) were treated with the actin-depolymerizing agent latrunculin A. Immunostaining revealed that actin filaments within presynaptic motor terminal boutons were disrupted by the drug. In preparations loaded with the optical probe(More)
Nearly 30 years ago, a debate over two disparate models of synaptic vesicle retrieval arose. Subsequent investigations to determine which model was correct proved inconclusive and served only to further the debate. However, recent evidence has begun to suggest that both models are valid and relevant in understanding the complex nature of vesicle recycling.
This study has investigated the patterns of membrane 2H4 (CD45RA) and UCHL1 (CD45RO) expression by CD4+ and CD8+ lymphocyte subpopulations in 10 adults and seven children with common variable immunodeficiency (CVI) and X-linked hypogammaglobulinaemia (XLA). Of the 10 adults (CVI, n = 8; XLA, n = 2), only one with a diagnosis of CVI showed normal CD45R(More)
The differential expression of various membrane CD45R isoforms by normal lymphocyte populations is known to be closely associated with distinct immunoregulatory functions. Abnormal patterns of CD45R expression have been reported in patients with common variable immunodeficiency and HIV infection, and recent evidence has suggested the possibility that one(More)
Pyracantha, photinia, and dwarf Burford holly were treated with a uniconazole medium drench at 0, 0.5, 1.0, or 3.0 mg · container−1 a.i. or a foliar application at the following rates: pyracantha at 0, 50, 100, or 150 mg · L−1 a.i.; photinia at 0, 25, 50, or 100 mg · L−1 a.i.; and holly at 1, 10, 25, or 50 mg · L−1 a.i. Height, width, leaf area per plant,(More)
The effect of various sources of Fe, Mn and Zn on growth and visual quality of geranium (Pelargonium hortorum L. ‘Orbit Red’) seedlings, nutrient leaching, and nutrient distribution in the growing medium was determined in two experiments. In the first experiment, Fe, Mn and Zn were applied as a commercially formulated water soluble fertilizer (WSF),(More)
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