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OBJECTIVE Peripheral neuropathy is common among people with diabetes and can result in foot ulceration and amputation. The aim of this study was to quantify the annual medical costs of peripheral neuropathy and its complications among people with type 1 and type 2 diabetes in the U.S. RESEARCH DESIGN AND METHODS A cost-of-illness model was used to(More)
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32(More)
We recently described a carrier-mediated nuclear transport system for tRNA in Xenopus laevis oocytes. A natural human tRNAimet variant with a G to T transversion in position 57 is defective in transport across the nuclear membrane. In addition, processing of the primary transcript of the variant gene is much less efficient than the wild type. We now(More)
In eukaryotes pre-tRNA species are processed at the 5' end by an endonuclease. Here we describe the first characterization of the structure of a eukaryotic pre-tRNA 5' processing endonuclease. The 5' pre-tRNAase, isolated from X. laevis ovaries, copurifies with a 16S macromolecular complex consisting of at least 14 polypeptides ranging in MW from about(More)
SUMMARY A plasmid that is able to replicate in both Escherichia coli and Streptococcus sanguis has been constructed by the in vitro joining of the pACYC184 (Cm' Tc') and pVA749 (Em') replicons. This plasmid, designated pVA838, is 9.2 kb in size and expresses Em' in both E. coii and S. sang&. Its Cm' marker is expressed only in E. eoli and may be inactivated(More)
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